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Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in the world that represents an important public health challenge nowadays. Lifestyle changes and exercise can reduce the development of fatty liver. The aim of this systematic review and meta-analysis is to evaluate the treatment efficacy of Qigong for NAFLD. Methods: A detailed search for articles up to September 2020 will be performed to identify randomized controlled trials for Qigong in NAFLD. The following database will be used: PUBMED, Embase, Web of Science, Cochrane Library, Sino Med, Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodicals Database, and Wanfang Databas. Grey literature will be explored and the selection of studies, data extraction and validation will be performed independently by 2 reviewers using predefined selection criteria and quality indicators. Stata V.13.0 and Review manager 5.3 software will be used for data synthesis, sensitivity analysis, subgroup analysis, and risk of bias assessment. We will use the grading of recommendations assessment, development, and evaluation system to assess the quality of evidence. Results: This research will provide a quantitative and standardized assessment of the treatment efficacy of Qigong for NAFLD. Conclusion: This systematic review will generate the latest evidence for determining whether Qigong has a positive treatment effect for NAFLD. Registration number: INPLASY202090034

Review question / Objective: We will include patients with NAFLD irrespective of gender, race, age, and setting. We excluded patients with any signs of mental illness or organic disease. Using Qigong exercises for NAFLD patients. Included variation in intensity, frequency and duration will be accepted. Conventional treatment or exercise according to relevant guideline, or other forms of Qigong such as Tai Chi, Baduanjin, etc. Studies that compared Qigong plus another therapy with the same INPLASY 1

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