The growth of colloidal nanocrystal architectures by nanoparticle attachment is frequently reported as an alternative to the conventional growth by monomer attachment. However, the mechanism whereby nanoparticle attachment proceeds microscopically remains unclear. We report real-time transmission electron microscopy (TEM) imaging of the solution growth of Pt(3)Fe nanorods from nanoparticle building blocks. Observations revealed growth of winding polycrystalline nanoparticle chains by shape-directed nanoparticle attachment followed by straightening and orientation and shape corrections to yield single-crystal nanorods. Tracking nanoparticle growth trajectories allowed us to distinguish the force fields exerted by single nanoparticles and nanoparticle chains. Such quantification of nanoparticle interaction and understanding the growth pathways are important for the design of hierarchical nanomaterials and controlling nanocrystal self-assembly for functional devices.

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Aim: To examine the expression profile of FMO1 in papillary thyroid cancer (PTC) and its prognostic value in recurrence-free survival (RFS). Methods: A retrospective analysis was performed using data from the Cancer Genome Atlas and Human Protein Atlas. Results: The most frequent variants of PTC had decreased FMO1 expression compared with their respective adjacent normal tissues. However, even under the best cut-off model, high FMO1 expression was only significantly associated with better RFS in classical PTC (p < 0.001), but not in other two variants. High FMO1 expression independently predicted favorable RFS (hazard ratio: 0.202; 95% CI: 0.084–0.487; p < 0.001) in classical PTC. Conclusion: High FMO1 expression might serve as a biomarker that independently predicts favorable RFS in classical PTC patients.