Textile-based triboelectric nanogenerators (TENG) that can effectively harvest biomechanical energy and sense multifunctional posture and movement have a wide range of applications in next-generation wearable and portable electronic devices. Hence, bulk production of fine yarns with high triboelectric output through a continuous manufacturing process is an urgent task. Here, an ultralight single-electrode triboelectric yarn (SETY) with helical hybridized nano-micro core–shell fiber bundles is fabricated by a facile and continuous electrospinning technology. The obtained SETY device exhibits ultralightness (0.33 mg cm–1), extra softness, and smaller size (350.66 μm in diameter) compared to those fabricated by conventional fabrication techniques. Based on such a textile-based TENG, high energy-harvesting performance (40.8 V, 0.705 μA cm–2, and 9.513 nC cm–2) was achieved by applying a 2.5 Hz mechanical drive of 5 N. Importantly, the triboelectric yarns can identify textile materials according to their different electron affinity energies. In addition, the triboelectric yarns are compatible with traditional textile technology and can be woven into a high-density plain fabric for harvesting biomechanical energy and are also competent for monitoring tiny signals from humans or insects.

Although challenging, fabrication of porous conducting polymeric materials with excellent electronic properties is crucial for many applications. We developed a fast in situ polymerization approach to pure polyaniline (PANI) hydrogels, with vanadium pentoxide hydrate nanowires as both the oxidant and sacrifice template. A network comprised of ultrathin PANI nanofibers was generated during the in situ polymerization, and the large aspect ratio of these PANI nanofibers allowed the formation of hydrogels at a low solid content of 1.03 wt %. Owing to the ultrathin fibril structure, PANI hydrogels functioning as a supercapacitor electrode display a high specific capacitance of 636 F g, a rate capability, and good cycling stability (∼83% capacitance retention after 10,000 cycles). This method was also extended to the preparation of polypyrrole and poly(3,4-ethylenedioxythiophene) hydrogels. This template polymerization method represents a rational strategy for design of conducing polymer networks, which can be readily integrated in high-performance devices or a further platform for functional composites.

Inhibition of stearoyl-CoA desaturase 1 (SCD1) has been found to effectively suppress tumor cell proliferation and induce apoptosis in numerous neoplastic lesions. However, mechanism underlying SCD1-mediated anti-tumor effect has maintained unclear. Herein, we reported endo-lipid messenger ceramides played a critical role in tumor fate modulated by SCD1 inhibition. In vitro study in colorectal cancer cells demonstrated inhibition of SCD1 activity promoted apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species (ROS), alteration of mitochondrial transmembrane potential and translocation of mitochondrial protein cytochrome C. While these effects were mediated by intracellular ceramide signals through induction of ceramide biosynthesis, rather than exclusive SFA accumulation. In vivo study in xenograft colorectal cancer mice showed pharmacologic administration of SCD1 inhibitor A939 significantly delayed tumor growth, which was reversed by L-cycloserine, an inhibitor of ceramide biosynthesis. These results depicted the cross-talk of SCD1-mediated lipid pathway and endo-ceramide biosynthesis pathway, indicating roles of ceramide signals in SCD1-mediated anti-tumor property.

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