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BackgroundThe prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration.MethodsThis retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects.ResultsThe serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS.ConclusionsThe serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS.

Abstract. Emergency responders often have to operate and respond to emergency situations during dynamic weather conditions, including floods. This paper demonstrates a novel method using existing tools and datasets to evaluate emergency responder accessibility during flood events within the city of Leicester, UK. Accessibility was quantified using the 8 and 10 min legislative targets for emergency provision for the ambulance and fire and rescue services respectively under "normal" no-flood conditions, as well as flood scenarios of various magnitudes (1 in 20-year, 1 in 100-year and 1 in 1000-year recurrence intervals), with both surface water and fluvial flood conditions considered. Flood restrictions were processed based on previous hydrodynamic inundation modelling undertaken and inputted into a Network Analysis framework as restrictions for surface water and fluvial flood events. Surface water flooding was shown to cause more disruption to emergency responders operating within the city due to its widespread and spatially distributed footprint when compared to fluvial flood events of comparable magnitude. Fire and rescue 10 min accessibility was shown to decrease from 100, 66.5, 39.8 and 26.2 % under the no-flood, 1 in 20-year, 1 in 100-year and 1 in 1000-year surface water flood scenarios respectively. Furthermore, total inaccessibility was shown to increase with flood magnitude from 6.0 % under the 1 in 20-year scenario to 31.0 % under the 1 in 100-year flood scenario. Additionally, the evolution of emergency service accessibility throughout a surface water flood event is outlined, demonstrating the rapid impact on emergency service accessibility within the first 15 min of the surface water flood event, with a reduction in service coverage and overlap being observed for the ambulance service during a 1 in 100-year flood event. The study provides evidence to guide strategic planning for decision makers prior to and during emergency response to flood events at the city scale. It also provides a readily transferable method for exploring the impacts of natural hazards or disruptions in other cities or regions based on historic, scenario-based events or real-time forecasting, if such data are available.