A comparative, randomized trial was conducted to determine the efficacy of oral UFT® (Tegafur and Uracil) versus 5-fluorouracil (5-FU) in combination with cyclophosphamide and doxorubicin in patients with metastatic breast cancer. Of 62 evaluable patients, 31 received UFT® (350 mg/m²/day orally x 14 days), doxorubicin (50 mg/m² intravenously [IV] day 1) and cyclophosphamide (500 mg/m² IV day 1). The other 31 patients received 5-FU (500 mg/m² IV days 1 and 8), doxorubicin (50 mg/m² IV day 1), and cyclophosphamide (500 mg/m² IV day 1). Regimens were repeated for a total of six cycles. The two groups were comparable in terms of age, gender, performance status, menopausal status, and number and sites of metastases. No statistical difference in overall response rates was seen (UFT® arm, 48.4% vs. 5-FU arm, 35%; p = 0.30). Median response duration was 16 weeks (range, 4–30) for both arms. The toxicity profile (alopecia, anemia, leukopenia, thrombocytopenia, diarrhea) was similar in both groups and both regimens were well tolerated. Anemia and stomatitis were significantly more common in the 5-FU arm (p = 0.02). Thus, oral UFT® has response rates and duration of response that are comparable to 5-FU in a combination regimen for advanced breast cancer.

No abstract

We are sad to say farewell to a great person, Dr. Dwight Jerry Easterly. He has been a good son, husband, father, and a friend and colleague to those in the aerospace and space communi�es. He will be sorely missed and will always be remembered for his con�nued dedica�on to the Canaveral Council of Technical Socie�es, both in its leadership and its organiza�on of several Space Congress symposia, and for his work in the American Society of Mechanical Engineers. Dr. Dwight Easterly contributed to the aerospace and space industries in the U.S. and Germany, working as an academic and a professional. He earned a bachelor's degree, two master's degrees, and a doctoral degree. Dr. Easterly had many diverse hobbies including scuba diving and hot air ballooning, but most of all he loved traveling and spending �me with family and friends. Along with his accomplishments, Dwight was passionate about the Cape Canaveral Technical Socie�es (CCTS)'s Space Congress. He was involved in decades worth of CCTS's Space Congress symposia, both during the Space Shu�le Era and in the space industry's transi�on to increased commercial spaceflight. He a�ended or organized every Space Congress in existence, even presiding as General Chair of the 43rd Space Congress. Dr. Easterly is survived by his significant other, Karen Rosse�er; four children, K.C. Easterly, Kristen Geeraerts, Jerry Easterly, and Sandy Harlow; and six grandchildren. Dwight, we will miss you! 44th Space Congress® The Journey: Further Exploration for Universal Opportunities May 24-26, 2016 Radisson Resort at the Port Cape Canaveral, Florida Welcome to the 46th Space Congress ® Evening Banquet "Apollo 50th Anniversary Celebration"