The present study aimed to develop a cryotherapy gel based on ginger, menthol and caffeine, as well as to analyze the parameters of physical-chemical and microbiological quality control of the phytocosmetic formulation. The raw materials were purchased in local stores in the municipality of Teresina, Piauí. The ginger extract was obtained by macerating the rhizomes and rotating with acetone solvent. For the cosmetic formulation, carbopol gel was first prepared, followed by alkalinization, solubilization in caffeine and menthol and addition of ginger extract and dye, following the Good Practices of Handling the Resolution of the Collegiate Board (RDC) No. 67 / 2007. Subsequently, the physical-chemical quality control tests inherent to the preliminary stability were applied, encompassing organoleptic characteristics, pH, electrical conductivity, spreadability, resistance to centrifugation, optical microscopy, in addition to microbiological evaluation, identifying the presence of mesophilic bacteria, filamentous fungi and yeasts. The results of the organoleptic characteristics indicated a gel with a bright red color, homogeneous appearance and a characteristic menthol odor. The pH ranged from 5.46 to 5.59 and the electrical conductivity from 1900 to 2250 µs / cm, both being considered adequate. Regarding the spreadability, it was found that there was an increase in the proportion that the weight (g) was added, showing a good ability to spread and cover the site of action, both before and after preliminary stability. In the centrifugation resistance test, the gel formulation remained stable, both before and after 12 days. Regarding the microscopic analysis of the droplets, it was observed that most of them (65%) had a diameter in the range of 0.6 µm to 1 µm, showing small blood cells heterogeneously distributed and with some coalescence points. As for the microbiological analyzes of the cryotherapy gel, it was observed that the values for counting microrganisms were within the limits recommended by the Brazilian Pharmacopoeia, both for aerobic mesophiles (1UFC / g) and for filamentous fungi and yeasts (0 CFU/g). Thus, it was possible to develop a phytocosmetic suitable for use, with pleasant organoleptic characteristics and physical-chemical and microbiological standards within the required prerequisites. However, it is necessary to carry out new tests of product stability during the entire storage, in order to confirm the preliminary results, in addition to tests that ratify its biological activity, as well as in vitro and in vivo toxicological tests that effectively guarantee product safety.
