This study examined the individual and collective influence of conspiracy theories, misinformation and knowledge revolving around COVID-19, on public adoption of the Nigerian government’s containment policies. The study adopted the Survey, and Focus Group Discussion (FGD) methods. For the survey, a sample of 466 respondents were drawn from Facebook, Instagram, Messenger and WhatsApp, while 24 participants were selected for the FGD. The Statistical Package for Social Sciences (SPSS) and thematic approach were used to analyse data generated from the study. Results revealed a COVID-19 conspiratorial thinking among survey respondents and FGD participants, who were also familiar with the orgy of unbridled dissemination of misinformation and conspiracy theories in the social media space. Majority of respondents were knowledgeable about government’s COVID-19 containment policies and were practicing the recommended safety measures. Their decision was influenced by trust in opinion leaders, especially family members and medical experts.