Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ETA and ETB receptors. Our goal was to evaluate the effects of alcohol and diabetes and their relationship to miRNA-155, miRNA-199 and endothelin receptors in the corpus cavernosum and blood of rats submitted to the experimental model of diabetes mellitus and chronic alcoholism. Forty-eight male Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D), and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study the protein expression of endothelin receptors by immunohistochemistry and expression of miRNAs-155 and -199 in serum and the cavernous tissue. Immunostaining for endothelin receptors was markedly higher in the A, D, and AD groups than in the C group. Moreover, a significant hypoexpression of the miRNA-199 in the corpus cavernosum tissue from the AD group was observed, compared to the C group. When analyzing the microRNA profile in blood, a significant hypoexpression of miRNA-155 in the AD group was observed compared to the C group. The miRNA-199 analysis demonstrated significant hypoexpression in D and AD groups compared to the C group. Our findings in corpus cavernosum showed downregulated miRNA-155 and miRNA-199 levels associated with upregulated protein expression and unaltered mRNA expression of ET receptors suggesting decreased ET receptor turnover, which can contribute to erectile dysfunction in diabetic rats exposed to high alcohol levels.

We study homomorphisms between Fréchet algebras of holomorphic functions of bounded type. In this setting we prove that any pointwise bounded homomorphism into the space of entire functions of bounded type is rank one. We characterize up to the approximation property of the underlying Banach space, the weakly compact composition operators on Hb(V), V absolutely convex open set.

Background: Musculoskeletal disorders in welders may influence their health-related quality of life. However, few studies have addressed this issue and their results were inconclusive. This study investigates whether there are musculoskeletal disorders with a higher incidence in welders compared to non-welders, and whether these disorders lead to an increase in bodily pain which in turn decreases their health-related quality of life.Methods:A priori analyses of statistical power were conducted to determine the sample size needed to find medium to large statistical effects, for a 0.05 alpha, and critical sampling, combined with snowball sampling, was carried out. The study was cross-sectional, and participants were asked to respond to a survey using validated instruments (Nwelders = 40, Nnon−welders = 42).Results: As expected, a higher incidence of symptoms of musculoskeletal disorders in the cervical, dorsal, lumbar, and wrists and hands was found in welders in comparison to non-welders. Furthermore, the presence of musculoskeletal disorders, particularly in the lumbar area, was related to an increased bodily pain and decreased health-related quality of life.Conclusion: Welders are exposed to a higher incidence of musculoskeletal disorders that decrease their quality of life. It is essential to increase the awareness of welders, organizations, and regulatory institutions toward this issue in order to motivate the development and implementation of prevention strategies. The need for primary and secondary prevention-type strategies, which have already proven their effectiveness in the context of welding, is highlighted.

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