2012Monocyte-derived dendritic cells from breast cancer patients are biased to induce CD4(+)CD25(+)Foxp3(+) regulatory T cells JOURNAL OF LEUKOCYTE BIOLOGY, BETHESDA, v. 92, n. 3, pp. 673-682, SEP, 2012 ϩ , suppressed mitogen-stimulated T cells. Contrastingly, Mo-DCs from healthy donors induced a stronger proliferative response, a low frequency of CD4 ϩ CD25 ϩ Foxp3 ϩ with no suppressive activity. Furthermore, healthy Mo-DCs induced higher levels of IFN-␥, whereas the Mo-DCs of patients induced higher levels of bioactive TGF-␤1 and IL-10 in cocultures with allogeneic T cells. Interestingly, TGF-␤1 blocking with mAb in cocultures was not enough to completely revert the Mo-DCs of patients' bias toward Treg induction. Altogether, these findings should be considered in immunotherapeutic approaches for cancer based on Mo-DCs. J. Leukoc. Biol. 92: 673-682; 2012.

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