Several food contact materials (FCMs) contain non-intentionally added substances (NIAS), and most of the substances that migrate from plastic food packaging are unknown. This review aimed to situate the main challenges involving unknown NIAS in plastic food packaging in terms of identification, migration tests, prediction, sample preparation, determination methods and risk assessment trials. Most studies have identified NIAS in plastic materials as polyurethane adhesives (PU), polyethylene terephthalate (PET), polyester coatings, polypropylene materials (PP), multilayers materials, plastic films, polyvinyl chloride (PVC), recycled materials, high-density polyethylene (HDPE) and low-density polyethylene (LDPE). Degradation products are almost the primary source of NIAS in plastic FCMs, most from antioxidants as Irganox 1010 and Irgafos 168, following by oligomers and side reaction products. The NIAS assessment in plastics FCMs is usually made by migration tests under worst-case conditions using food simulants. For predicted NIAS, targeted analytical methods are applied using GC-MS based methods for volatile NIAS and GC-MS and LC-MS based methods for semi- and non-volatile NIAS; non-targeted methods to analyze unknown NIAS in plastic FCMs are applied using GC and LC techniques combined with QTOF mass spectrometry (HRMS). In terms of NIAS risk assessment and prioritization, the threshold of toxicological concern (TTC) concept is the most applied tool for risk assessment. Bioassays with sensitive analytical techniques seem to be an efficient method to identify NIAS and their hazard to human exposure; the combination of genotoxicity testing with analytical chemistry could allow the Cramer class III TTC application to prioritize unknown NIAS. The scientific justification for implementing a molecular weight-based cut-off (<1000 Da) in the risk assessment of FCMs should be reevaluated. Although official guides and opinions are being issued on the subject, the whole chain’s alignment is needed, and more specific legislation on the steps to follow to get along with NIAS.

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Please cite this article as: Kato, L.S., de Nadai Fernandes, E.A., Raab, A., Bacchi, M.A., Feldmann, J., Arsenic and cadmium contents in Brazilian rice from different origins can vary more than two orders of magnitude, Food Chemistry (2019), doi: https://doi. AbstractBrazil is a major producer of rice, but there is not enough information about As and Cd in rice grown under different conditions in this country. Here, As and Cd were determined by ICP-MS and species of As by HPLC-ICP-MS in Brazilian husked rice, covering diverse cultivars and regions, as well as upland and flooded production systems. Significant differences were observed for both elements contents according to the origin of rice. All samples were below the maximum limit for Cd (400 µg/kg) set by national legislation, while nine samples presented total As above the legislation limit (300 µg/kg). From 24 samples analyzed for As species, 42% showed iAs above the European limit for production of food to infants (100 µg/kg). The total As content in samples from Mato Grosso state presented a maximum value of 6 µg/kg, which combined with low Cd content make interesting further studies. Highlights The total As varied by two orders of magnitude (<2.6 µg/kg to 630 µg/kg)  Cd content was always below the maximum limit stablished by regulatory authorities  Upland rice from Mato Grosso contain the lowest ever measured As contents  Brazilian rice from flooded system contains iAs from 68 to 174 µg/kg  Twenty samples were above the limit of iAs in rice destined to food for infants

Metals, many of which are potentially toxic, are present in the aquatic environment originated from both natural and anthropogenic sources. In these ecosystems, these elements are mostly deposited in the sediment, followed by water dissolution, potentially contaminating resident biota. Among several aquatic animals, crustaceans are considered excellent bioindicators, as they live in close contact with contaminated sediment. The accumulation of metal, whether they are classified as essential, when in excessive quantities or nonessential, not only cause damage to the health of these animals, but also to the man who consumes seafood. Among the main toxic elements to animal and human health are aluminum, arsenic, cadmium, chromium, copper, lead, mercury, nickel and silver. In this context, this systematic review aimed to investigate the dynamics of these metals in water, the main bioaccumulative tissues in crustaceans, the effects of these contaminants on animal and human health, and the regulatory limits for these metals worldwide. A total of 91 articles were selected for this review, and an additional 68 articles not found in the three assessed databases were considered essential and included, totaling 159 articles published between 2010 and 2020. Our results indicate that both chemical speciation and abiotic factors such as pH, oxygen and salinity in aquatic environments affect element bioavailability, dynamics, and toxicity. Among crustaceans, crabs are considered the main bioindicator biological system, with the hepatopancreas appearing as the main bioaccumulator organ. Studies indicate that exposure to these elements may result in nervous, respiratory, and reproductive system effects in both animals and humans. Finally, many studies indicate that the concentrations of these elements in crustaceans intended for human consumption exceed limits established by international organizations, both with regard to seafood metal contents and well as daily, weekly, or monthly intake limits set for humans, indicating consumer health risks.