With growing pressure to contribute to their region's development, universities are increasingly called upon to engage dynamically in innovation policy-making and governance activities. Previous studies suggest in their collaboration with local and regional government that universities can emerge as animateurs, providing guidance, consolidating networks, and ultimately activating institutional and human agency. This is especially important in the context of less-developed regions, where the unlocking of innovative potential may rest on those factors. This paper provides an extended perspective on universities' engagement in innovation policy processes and, in a broader sense, on the collaboration between these higher education institutions and local and regional government. Through an analysis of the partnership between two Portuguese institutions, the University of Aveiro and the intermunicipal community of the region of Aveiro, this study explores the potential implications on regional innovation policy and the activation of institutional agency in a less-developed context. Policy documents, reports and interview data from 18 academics, top managers, policy-makers and other stakeholders show that while institutional expectations differ, collaborative interplays have boosted the formation and growing effectiveness of regional innovation networks, crucial for the development of less-developed regions. ARTICLE HISTORY

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The emergence of collaborative approaches in innovation policy and regional governance has increased expectations for universities to engage in strategy making and assume broader roles and responsibilities. Nonetheless, complexities inherent to the policy process, regional context and universities’ own institutional and organisational capacity are often ignored or under-explained when framing universities’ roles. Although these roles are frequently introduced, they have been superficially conceptualised in the literature. This study develops a deeper theoretical and empirical understanding of universities’ contributions in the different stages of regional innovation strategy processes. Through a comparative case study of four European universities, it explores the variation of these roles by policy stage and university actors involved in the strategies. Findings suggest universities have expanded to perform new planning-related roles (e.g. consultation, mediation) and that diverse factors (e.g. the regional context, such as urban versus peripheral) determine their participation in regional strategies. However, strategic coordination within universities and with regional bodies is needed for the optimisation of their engagement in the regional governance process. JEL Codes: I23, I25, O20, O30, R58

Universities are expected to play a leading role in the smart specialisation strategy process, However, a gap between discourse and practice is marking the RIS3-related regional development programmes, which can be extended to the involvement of universities in the process. A mismatch can be speculated between the expectations towards universities' roles in RIS3 implementation and actual practice, and its repercussions on a regional innovation ecosystem. This chapter addresses the extent to which the role played by universities in a region's innovation and entrepreneurial practice aligns with the smart specialisation strategic outline. As an in-depth case-study of the University of Aveiro (Portugal), it draws on both quantitative and qualitative data, with an analysis of RIS3 approved projects in the Portuguese NUTS II Centro region, and interviews with key actors within the university and the regional administration. Through this, it weighs the contribution of entrepreneurial universities to the RIS3 goals, drawing lessons for public policy and discussing the future of RIS3.