This paper highlights the potential of discrete wavelet transforms in the analysis and comparison of genomic sequences of Mycobacterium tuberculosis (MTB) with different resistance characteristics. Graphical representations of wavelet coefficients and statistical estimates of their parameters have been used to determine the extent of similarity between different sequences of MTB without the use of conventional methods such as Basic Local Alignment Search Tool. Based on the calculation of the energy of wavelet decomposition coefficients of complete genomic sequences, their broad classification of the type of resistance can be done. All the given genomic sequences can be grouped into two broad categories wherein the drug resistant and drug susceptible sequences form one group while the multidrug resistant and extensive drug resistant sequences form the other group. This method of segregation of the sequences is faster than conventional laboratory methods which require 3–4 weeks of culture of sputum samples. Thus the proposed method can be used as a tool to enhance clinical diagnostic investigations in near real-time.

An extended instrumental variable (EIV) method is considered for the stochastic Hammerstein system (ARMAX and general model structure). The EIV method provides consistent parameter estimates by eliminating noise-induced bias in the least square (LS) method. To estimate the parameters, the Hammerstein model is formulated using the bilinear parameterization. The bilinear model is identified by introducing the nonlinear instrumental variables obtained from transformed delayed outputs using nonlinear mapping and polynomial basis of delayed inputs. These instruments are analyzed in full generality by computing the bounds on expected relationship between instruments and noise for the general noise disturbance structure. Then, a specific case with hyperbolic tangent (tanh) transformation is considered. Comparative performance analysis of the proposed IV method with the existing IV method, the data filtering-based LS methods, and the extended LS method shows improvement in the statistical properties of parameters estimates.

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