A patient with urinary calculi measuring 4.3mm and 4.5mm in the lower pole of the right kidney, and a calculus measuring 4.5mm in the lower pole of the left kidney, presented to the OPD of Dr D Y Patil Homoeopathic Medical College and Research Centre, Pune, Maharashtra, with complaints of pain in the right iliac region extending to the genitals and legs, dribbling urine, and painful micturition. The patient had never received therapy previously. Generally, the stones in the lower pole of the kidneys do not pass spontaneously and require active treatment. Regular follow-ups were taken and USG-KUB was repeated. Lycopodium Clavatum 30C was administered based on the presenting symptoms & the constitutional totality and it proved efficient in the disintegration and expulsion of all the stones. Hence Homoeopathy proves efficacious in the fragmentation and expulsion of Renal calculi if the correct simillimum is administered.