Ankle sprain Injury is one of the most common ankle injuries due to domestic or sporting accidents. There is a need for greater demand for quick and effective ankle rehabilitation system (ARS). Nowadays, research on ARS has gained a great attention than manual clinical method in medical areas such as orthopedic injuries, pediatrics sport medicine and industrial services. It can improve the treatment conditions by reducing the dependency of doctors’ supervision, help patient with less movable to have home-based rehab exercise and help to speeds up recovery. There are currently available ARS that can provide effective ankle rehabilitation treatment such as Visual, Non-Visual and Robot-aided. In this paper, the critical review of ARS is conducted to evaluate the effectiveness of ARS in terms of provided setting criteria. The strengths, weaknesses, opportunities and threats of each ARS is discussed and compared to identify the most suitable home application of ARS for ankle sprain patient. From the comparison, the most suitable home application ARS is the visual marker-less based ARS system which give user-friendly, efficiency, validity in performance and cheaper cost.