Cutting Styrofoam manually will result in inaccurate cutting and dissimilar shape. To upgrade the quality of the product, a Styrofoam cutting machine which can cut automatically is needed. Thus, the aim of this research is to create a Styrofoam cutting machine using CNC 2 Axis Wire Cutter which can cut the material according to the CAD drawing module, and accelerate the cutting process. The control system of the machine uses the Arduino UNO microcontroller. The cutting process is performed by sending G-Code file to the microcontroller through the Universal G-Code Sender software. Afterwards, the microcontroller sends a signal to activate the stepper motor, and it is generated actuator movement according to the drawing in G-code file. The optimal Styrofoam cutting resulted by using CNC Wire Cutter with 0.2 mm nickel wire, 220oC, and 2 cm thickness.