Nonmuscle myosin II inhibition (NMIIi) in the basolateral amygdala (BLA), but not dorsal hippocampus (CA1), selectively disrupts memories associated with methamphetamine (METH) days after learning, without retrieval. However, the molecular mechanisms underlying this selective vulnerability remain poorly understood. A known function of NMII is to transiently activate synaptic actin dynamics with learning. Therefore, we hypothesized that METH-associated learning perpetuates NMII-driven actin dynamics in synapses, leading to an extended window of vulnerability for memory disruption. We used time-lapse two-photon imaging of dendritic spine motility in acutely prepared brain slices from female and male mice following METH-associated learning as a readout of actin-myosin dynamics. Spine motility was persistently increased in the BLA, but not in CA1. Consistent with the memory disrupting effect of intra-BLA NMII inhibition, METH-induced changes to BLA spine dynamics were reversed by a single systemic injection of an NMII inhibitor. Intra-CA1 NMII inhibition, on the other hand, did not disrupt METH-associated memory. Thus, we report identification of a previously unknown ability for spine actin dynamics to persist days after stimulation and that this is under the control of NMII. Further, these perpetual NMII-driven spine actin dynamics in BLA neurons may contribute to the unique susceptibility of METH-associated memories.

The COVID-19 outbreak, a recent major public health emergency, was the first national health crisis since China entered the era of mobile social media. In this context, the public posted many quarantine-related posts for help on social media. Most previous studies of social media during the pandemic focused only on people’s emotional needs, with less analysis of quarantine help-seeking content. Based on this situation, this study analyzed the relationship between the number of quarantine help-seeking posts and the number of new diagnoses at different time points in the pandemic using Zhihu, the most comprehensive topic discussion platform in China. It showed a positive correlation between the number of help-seeking posts and the pandemic’s severity. Given the diversity of people’s help-seeking content, this study used topic model analysis and sentiment analysis to explore the key content of people’s quarantine help-seeking posts during the pandemic. In light of the framework of uses and gratifications, we found that people posted the most questions in relation to help with information related to pandemic information and quarantine information. Interestingly, the study also found that the content of people’s quarantine posts during the pandemic was primarily negative in sentiment. This study can thus help the community understand the changes in people’s perceptions, attitudes, and concerns through their reactions to emergencies and then formulate relevant countermeasures to address pandemic control and information regulation, which will have implications for future responses to public health emergencies. Moreover, in terms of psychological aspects, it will help implement future mental health intervention strategies and better address the public’s psychological problems.

To date, it is still unclear how word structure might impact lexical processing in the brain for languages with an impoverished system of grammatical morphology such as Chinese. In this study, concurrent electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) recordings were performed to inspect the temporal and spatial brain activities that are related to Chinese word structure (compound vs. derivation vs. non-morphological) effects. A masked priming paradigm was utilized on three lexical conditions (compound constitute priming, derivation constitute priming, and non-morphological priming) to tap Chinese native speakers’ structural sensitivity to differing word structures. The compound vs. derivation structure effect was revealed by the behavioral data as well as the temporal and spatial brain activation patterns. In the masked priming task, Chinese derivations exhibited significantly enhanced brain activation in the frontal cortex and involved broader brain networks as compared with lexicalized compounds. The results were interpreted by the differing connection patterns between constitute morphemes within a given word structure from a spreading activation perspective. More importantly, we demonstrated that the Chinese word structure effect showed a distinct brain activation pattern from that of the dual-route mechanism in alphabetic languages. Therefore, this work paved a new avenue for comprehensively understanding the underlying cognitive neural mechanisms associated with Chinese derivations and coordinate compounds.

Unlike single grouping principle, cognitive neural mechanism underlying the dissociation across two or more grouping principles is still unclear. In this study, a dimotif lattice paradigm that can adjust the strength of one grouping principle was used to inspect how, when, and where the processing of two grouping principles (proximity and similarity) were carried out in human brain. Our psychophysical findings demonstrated that similarity grouping effect was enhanced with reduced proximity effect when the grouping cues of proximity and similarity were presented simultaneously. Meanwhile, EEG decoding was performed to reveal the specific cognitive patterns involved in each principle by using time-resolved MVPA. More importantly, the onsets of dissociation between 2 grouping principles coincided within 3 time windows: the early-stage proximity-defined local visual element arrangement in middle occipital cortex, the middle-stage processing for feature selection modulating low-level visual cortex such as inferior occipital cortex and fusiform cortex, and the high-level cognitive integration to make decisions for specific grouping preference in the parietal areas. In addition, it was discovered that the brain responses were highly correlated with behavioral grouping. Therefore, our study provides direct evidence for a link between the human perceptual space of grouping decision-making and neural space of brain activation patterns.

As a morphological impoverished language, how does word structure impact Chinese lexical processing in the brain? To address this issue, the current study examined the temporal signatures and localizations in the human brain for morphological priming effect (compound/derivation constitute priming vs. non-morphological priming) and word structure modulation (derivation vs. compound) in light of EEG-fNIRS fusion. Whilst morphological priming effect was manifested in behavioral performance and left prefrontal hemodynamic responses, word structure effect was prominent drawing on behavioral, ERP, and fNIRS data. Chinese derivations elicited greater activation in the frontal cortex and engaged more distributed network than lexicalized compounds. The results were interpreted by the differing connection patterns between constitute morphemes within a given word structure from spreading activation perspective. Together, Chinese word structure effect showed a distinct pattern from the dual-route mechanism in alphabetic languages. Meanwhile, the current study for the first time identified dissociable behavioral and neurophysiological responses of Chinese derivations and coordinate compounds.