Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory condition characterized by tumefactive lesions that can affect multiple organs. Serum IgG4 levels may be elevated. Early recognition is sometimes difficult but is important to avoid irreversible organ damage. We describe the case of a 28-year-old male patient who presented with a 2-year history of recurrent low-grade fever, night sweats and non-specific manifestations. We eventually diagnosed IgG4-related aortitis by PET-CT scan. The patient was successfully treated with prednisolone and mycophenolate mofetil with complete clinical and radiological resolution.LEARNING POINTSIgG4-related disease is a systemic immune-mediated disease that can affect many organs and systems.Aortitis can be one of the differential diagnoses in patients with fever of unknown origin, back pain and other unspecific symptoms.Delayed diagnosis and treatment may cause major complications or irreversible damage, so timely diagnosis and appropriate treatment is very important.

Objective: To understand the current status of alcohol use in Macau secondary students and to explore the relationship between alcohol use behaviour in the students and various family factors. At the same time, the study also aimed to analyze the predictive power of various family factors on alcohol use, to provide a reference for the formulation of strategies for prevention and control of alcohol use in Macau adolescents. Material and Methods: The study was a cross-sectional study with data collection using a self-constructed questionnaire. The study samples were students in formal or vocational education in Macau in the school year 2020/2021, with randomization using randomized multistage stratified cluster sampling. A total of 939 valid samples were collected for data analysis. The distributions of the background variables and the behavior of alcohol use were analyzed using descriptive analysis, while Chi-square test (Chi-square), one-way analysis of variance (One-Way ANOVA), Kruskal-Wallis one-way analysis of variance, and logistic regression analysis were used for inferential statistical analysis. Conclusion: There is an increased risk of current alcohol use in the students whose siblings also have a drinking habit, who have helped family members buy alcohol, and whose parents are more positive about drinking and who think their parents do not care about them. Intervention measures should be formulated targeting these factors.

Objective: Aim of this study is to investigate the current condition of adolescent depression in Macau and its relation with family factors, and to provide a reference for formulating policy about the issue Material andMethods: The study used randomised multistage stratified cluster sampling. In March 2021, all students in normal education from Form 1 to Form 6 in day Secondary schools were eligible for study sampling. Patient Health Questionnaire-9 (PHQ-9) used to assess depression severity and a self-formulated questionnaire for investigation of family-related factors.. Results: There was total of 939 validated questionnaires, major depression occurred in 16.4% of the study samples, more females had depression than males (21.8% and 11.4%, respectively). Among all family factors, low-income family financial condition (monthly income <10000 MOP) (OR=2.71, 95% CI 1.02-7.21), parents not caring (OR=2.18, 95% CI 1.01-4.69), poor relationship with parents (OR=3.01, 95% CI 1.53-5.91) and often quarrel with parents (OR=3.39, 95%CI 2.12-5.42) had significant correlation with adolescent major depression. The study also noted that female adolescents with major depression were more affected by family factors. Conclusion: According to study results, Family factors and adolescent depression has correlation, it is advised that family intervention can be used as a reference for strategies on improving the adolescent depression problems.