The maximal aerobic power of 463 Chinese children and adolescents, 10–19 years, is described. The absolute values of maximal oxygen intake (V̇O2max) in boys and girls were 1.75–3.26 and 1.44–2.10 L/min, respectively. Relative values of V̇O2max per unit stature (V̇O2max/stature) were 12.35–19.42 ml/cm.min for boys and 10.18–13.42 ml/cm.min for girls, values per unit weight (V̇O2max/weight) were 48.60–56.59 ml/kg.min for boys and 39.34–45.56 ml/kg.min for girls, and values per estimated unit lean body mass (V̇O2max/lean‐body‐mass) were 58.98–65.28 ml/kg.min for boys and 54.90–59.04 ml/kg.min for girls. Maximal values of oxygen pulse (V̇O2max/HRmax) were 8.58–16.67 ml/beat for boys and 6.88–10.35 ml/beat for girls. In early adolescence, V̇O2max, V̇O2max/stature, and V̇O2max/HRmax increased with chronological age, but the increment was less in girls. In contrast, V̇O2max/weight and V̇O2max/LBM did not increase with age in boys and girls. All indicators of V̇O2max were lager in boys than in girls. © 1996 Wiley‐Liss, Inc.

Prior to pathological changes becoming apparent in any disease, the component and amount of intracellular proteins may undergo alteration. Thus, monitoring of proteins may be used to screen indicators in order to identify prognostic markers. The aim of this study was to investigate the feasibility of identification of serum biomarkers for lung cancer using protein mass spectrometry. Surface-enhanced laser desorption/ionization (SELDI) and weak cation exchange 2 (WCX2) protein chip array were employed for protein profiling of the sera of 17 healthy rabbits and 23 cancer‑bearing rabbits, of which 15 developed cancer in the lung (cancer group) and 8 developed lung cancer in the follow-up period (pre-cancer group). Data were obtained using a PBSII-C protein chip reader and analyzed using Biomarker Wizard and Proteinchip 3.1 software. Compared with the healthy rabbits, a total of 5 biomarkers were identified to be differentially expressed among 32 proteins screened from the sera in the cancer group and the pre-cancer group (P<0.05): 3 of the 5 biomarkers were upregulated and 2 were downregulated. Protein mass spectro-metry can be used to identify specific molecules closely correlated with the progression of lung cancer and, thus, this method may become an effective tool for the early diagnosis or prediction of lung cancer.

No abstract