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Background: Surgery in elder patients with intermural fibroids delays pregnancy, and GnRH-a can shrink uterine fibroids to a certain extent; therefore, for geriatric patients with fibroids, determining whether GnRH-a pretreatment before frozen–thawed embryo transfer (FET) can improve its success rate remains to be studied. We conducted this study to research whether GnRH-a pretreatment before hormone replacement treatment (HRT) could optimize the reproductive outcomes compared with others preparations in geriatric patients with intramural fibroids. Methods: According to the endometrial preparation, patients were divided into a GnRH-a–HRT group, a HRT group and a natural cycle (NC) group. The live birth rate (LBR) was the first outcome, and the clinical pregnancy outcome (CPR), the miscarriage rate, the first trimester abortion rate and the ectopic pregnancy rate were the secondary outcomes. Results: A total of 769 patients (aged 35 years or older) were included in this study. No significant difference was observed in the live birth rate (25.3% vs. 17.4% vs. 23.5%, p = 0.200) and the clinical pregnancy rate (46.3% vs. 46.1% vs. 55.4%, p = 0.052) among the three endometrial preparation regimens. Conclusion: In this study, for the geriatric patient with the intramural myoma, the pretreatment with GnRH-a did not show any advantage over the NC and HRT preparation groups before the FET, and the LBR was not significantly increased.

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The excellent performance and wide applications of phenyl polysiloxanes are largely due to their phenyl units and monomer sequences. However, the relationship between molecular structure and material properties has not been explicitly elucidated. In this work, the sequence distribution and microstructure of random copolymers were quantitatively investigated by means of a molecular dynamics (MD) simulation combined with experimental verification. The results of 29Si NMR showed that the large number of phenyl units not only shortened the length of the dimethyl units, but also significantly increased the proportion of consecutive phenyl units. The simulation results indicated the attraction between adjacent phenyl groups that were effectively strengthened intra- and inter- molecular interactions, which determined the equilibrium population of conformations and the dynamics of conformational transitions. Furthermore, the evolution of bond angle distribution, torsion distribution, and mean-squared displacements (MSD) shed light on the conformational characteristics that induce the unique thermodynamics properties and photophysical behavior of high-phenyl polysiloxanes. Differential scanning calorimetry (DSC), dynamical mechanical analysis (DMA), spectrofluorimetry, and laser scanning confocal microscopy (LSCM) were performed to verify the conclusions drawn from the simulation. Overall, the complementary use of MD simulations and experiments provided a deep molecular insight into structure–property relationships, which will provide theoretical guidance for the rational design and preparation of high-performance siloxanes.

The graded mineral aggregate composed of coarse aggregate, fine aggregate, and mineral powder is the main component of hot asphalt mixture (HMA), and it occupies a mass ratio of more than 95% in HMA. The gradation variability of mineral aggregate is frequently an unavoidable problem in the construction of asphalt pavement engineering. In order to investigate the effect of gradation variability on the volume parameters and key performances of HMA, the asphalt concrete with a nominal maximum particle size of 20 mm (AC20) was selected as the research carrier. Firstly, a benchmark mineral aggregate gradation (BMAG) was designed based on the theory of dense skeleton gradation presented in the paper. Secondly, six types of HMA (that is, AC20) with variable gradations were also determined and all the specimens were prepared by rotary compaction process with the same optimum asphalt content (gradation varies but asphalt content remains the same), and finally based on asphalt pavement analyzer, the performances of all the specimens of each gradation were tested. The results show that, compared with the BMAG-HMA, the volume parameters such as air voids, voids in mineral aggregate, and voids filled with asphalt of the variable-graded HMA change in different directions, but the water stability and high-temperature performance both degrade greatly. The experimental results also show the feasibility and effectiveness of the dense skeleton gradation design theory adopted in this study.