and the United States to present and discuss their work on the history of various aspects of scientific, technological, and medical knowledge production, including cartography, astrology, shipbuilding, natural history, medicine, and public health. Several invited senior scholars, whose research interests resonated with those of the participants, offered commentary, suggestions, and probing questions. Lively debates ensued concerning the similarities and differences of the various geopolitical Atlantics, as well as the epistemological and methodological implications of looking at the history of science and medicine from an Atlantic perspective. Although most of us had arrived at Harvard prepared to discuss the role of the Americas in ''the advancement of European science and medicine,'' a great deal of what we did actually served to challenge the assumptions implicit in the seminar's title. We came to be far more interested in understanding how transatlantic interactions shaped and were shaped by processes of knowledge production, and we became fascinated by the implications of using the Atlantic as a unit of analysis in the history of science, medicine, and technology. As a result, much of our discussion focused on recent models developed by scholars in Atlantic history could recast the received narratives of the history of science and medicine � an enterprise we might call an Atlantic history of science. 2 Equally intriguing for us, however, was the notion of a history of Atlantic science: rather than importing a methodology from Atlantic history, we felt we could create a new series of questions by redefining what knowledge was in the first place and questioning the circumstances of its production. For the purposes of this review essay, which seeks to capture the spirit of those early conversations in Cambridge, we propose calling the assemblages and interac tions of the peoples, objects, institutions, and techniques that resulted in and from colonization during the early modern period ''Atlantic science.'' We recognize, of