Clostridium perfringens type A is a Gram-positive anaerobic bacterium that inhabits the intestinal native biota of the intestine of birds. The objective of this review is to analyze different factors that predispose their pathogenicity and bacterial growth, leading to necrotic enteritis, a enterotoxemic disease characterized by hemorrhagic necrosis of the intestinal mucosa, affecting mainly broilers between 4 to 8 weeks of age or older, especially in poultry farms intensified, being a problem for morbidity and mortality hurting performance, weight, food, and due to its presence along the production of broilers, conversion it can be transmitted to humans through the consumption of contaminated poultry products. Its importance in the poultry field has led us to investigate alternatives to prevent and control the disease produced by Clostridium perfringens in poultry, and also reduce the proliferation and economic losses.