We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFAmediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected thiol into carboxylic acid containing building blocks through sulfa Michael additions onto a,b-unsaturated hexafluoroisopropyl esters is described. The stereoselectivity of the bicycle
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