Macrofungi are among the most promising sources of biologically active natural products with nutritional qualities and therapeutic values. In this work, the nutritional value of nine species of wild macrofungi from Ibague-Tolima (Colombia) was evaluated. In addition the antioxidant, antimicrobial and cytotoxic activities of an ethanol:water (70:30) extract of wild basidiomata were evaluated. The wild mushrooms’ nutritional potential showed that the genus Pleurotus and Lentinus have the best protein percentages, with 18.4% and 18.5%. The nine extracts evaluated managed to stabilize the two radicals evaluated; however, lower IC50 was found for Phellinus gilvus and Ganoderma australe extracts. The results showed that Trametes coccinea, Pleurotus floridanus and Ganoderma australe extracts were the most effective as antimicrobials, with high inhibition percentages against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Antifungal activity results against Rhizopus oryzae, Penicillium sp. and Aspergillus niger showed that the nine extracts were effective at the concentrations tested. Considering cell viability against isolated leukocytes, seven of the nine extracts showed percentages higher than 50% of cell viability. This research describes the nutritional value of nine wild macrofungi in Colombia and their potential for antimicrobial, cytotoxic and antioxidant activity.

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Macromycetes are an important factory of bioactive compounds, which have shown to have therapeutic use given their specific cytotoxicity, turning them into new and natural source of pharmaceuticals for treatments against several diseases. The purpose of this paper was to collect new data on the chemical and biological knowledge of the mycobiota that grows wild in the city of Ibagué (Colombia), in order to try to understand the cytotoxicity of these organisms. Based on abundance and chemotaxonomic criteria and in order to evaluate their biological activity, basidiomes of the following species were collected: Pycnoporus sanguineus, Phellinus gilvus, Pleurotus tubarius, Lenzites elegans and Ganoderma australe. An ethanolic maceration of basidiomes was used as base to perform cytogenotoxicity tests on Allium cepa. The extracts of P. sanguineus and G. australe inhibited A. cepa mitosis in 58.92 % at 8000 mg l -1 and 53.81% at 2000 mg l -1 , respectively. The extracts of the studied species have shown capacity to cause some genetic changes associated to the concentrations evaluated. This study shows that there is an important potential in wild macromycete biodiversity in the region of Tolima (Colombia), making them potential candidates for future research on clinical essays for the pharmaceutical industry.