Pengembangan formulasi ekstrak daun Salam (Syzygium polyanthum W.) sebagai antihiperlipidemia yang mampu hancur cepat setelah diletakkan di atas lidah sangat diperlukan untuk mempercepat onset obat dan memberikan kenyamanan terutama pada pasien hiperlipidemia usia lanjut yang sulit menelan obat. Tujuan dari penelitian ini untuk mengetahui komposisi perbandingan superdisintegrants crospovidone dan croscarmellose sodium yang mampu menghasilkan sifat fisik Fast Disintegrating Tablet (FDT) yang optimum. Pembuatan FDT menggunakan metode granulasi basah dengan variasi konsentrasi crospovidone dan croscarmellose sodium dalam rentang 2%-5%. Hasil uji sifat fisik FDT dianalisis menggunakan metode Simplex Lattice Design (SLD) program Design Expert 10.1.). Kombinasi kedua superdisintegrants dapat mempengaruhi respon sifat fisik yaitu mampu menurunkan kekerasan, waktu disintegrasi, waktu pembasahan dan meningkatkan kerapuhan FDT ekstrak daun salam. Formula optimum didapat pada kombinasi crospovidone dan croscarmellose sodium dengan perbandingan 25 mg : 10 mg dalam setiap 500 mg tablet. Formula optimum tersebut memiliki kekerasan 4,21 kg, kerapuhan 0,52%, waktu pembasahan 106,65 detik, dan waktu hancur 55,73 detik. Hasil analisis dengan one sample t-test menunjukkan persamaan SLD valid digunakan untuk menyusun formula yang memberikan parameter-parameter optimum FDT.

Gedoro village is one of the villages in Nglegi, Patuk, Gunung Kidul. This village is located in the north area of Gunung Kidul. This is an agricultural conservation area of herb Some of them are Zingiber oficinale (jahe), Curcuma xanthorrhiza (temulawak),Curcuma domestica (kunir) dan Cymbopogon citratus (serai). This village is located in hills where the access to transportation is quite difficult. This problem often causes delays in harvest distribution, so that a lot of herb rot before they are sold at the central market in Gunung Kidul. The survey result also showed that the people in Gedoro Village have not had enough knowledge in processing empon-empon into processed products that are able to increase its stability and durability when they are not immediately sold. Those problems are the factors which cause decrease in economic value of herb. Herb actually has high price because it contains antioxidants that can be used to treat cancer and degenerative diseases. The aim of this empowerment program is to increase the knowledge of people in Gedoro Village in processing herb into healthy drinks based on zero waste home industry with the women as the target. This program is in the format of KKN PPM which was given in the form of counseling, training, practicing and accompanying the processing of empon-empon into healthy drinks. This program is proven to be able to increase knowledge, skills and community participation as well as community self-help in processing herb into healthy drinks.

Water fraction of binahong (Anredera cordifolia (Ten.) Steen)  leaf has been proven to heal ulcus diabetic. In order to make the use easier and more practical, in this study the water fraction of binahong leaves is formulated in gel preparation form. This study was conducted to obtain a comparison of the amount of sodium alginate and carboxymethyl chitosan as gelling agent to produce gel that meets the good physical requirements. The method used to determine the amount of comparison of sodium alginate and carboxymethyl chitosan is to use Simplex Lattice Design (SLD). Eight variations of gel formula are designed with the ratio of sodium alginate:  carboxymethyl chitosan as follows: F1 (0:3% w/w), F2 (0:3% w/w), F3 (0.75:2.25% w/w), F4 (1.5:1.5 % w/w), F5 (1.5:1.5% w/w), F6 (2.25:0.75% w/w), F7 (3:0% w/w), F8 (3:0% w/w). Physical parameters observed included pH, viscosity, dispersion, and adherence. Data obtained compared with the actual conducted by researchers using one sample test t-test with 95% confidence level. Based on the results of the study, increased sodium alginate concentration can increase viscosity and adhesiveness and decrease the pH and spreadability of the gel. One sample t-test analysis shows that there is no significant difference between predicted parameter value and actual result so SLD equation can be used to construct gel formula of water fraction of binahong leaf. The conclusion is a combination of sodium alginate 1.546% w/w and carboxymethyl chitosan 1.454% w/w yield gel optimum. Physical parameter response of optimum formula is pH 5.86; viscosity 2000 cps; spreadability of 21,96 cm2; and adhesiveness of 19,81 seconds.

The lengkuas rhizome has an antifungal activity. The non-specific parameters for extracts of lengkuas rhizome need to be standardized to obtain the extracts with consistent good quality. The lengkuas rhizome extract emulgel topical preparations are easily mixed with active substances that are hydrophobic or hydrophilic. This study aims to obtain a lengkuas rhizome extract emulgel formula that has good quality and good physical properties. Extraction of lengkuas rhizome was obtained using a maceration method with 96% ethanol solvent. The extract is standardized by non-specific parameters. After that, the extract was formulated in the form of emulgel preparation with 10% concentration. The physical properties of emulgel were evaluated. The results of the study showed that the extract yield is of (14.66±0.056)%; powder drying shrinkage (8.63±0.134)%; extract water rate (5±0)%; powder total ash rate (3.24±0.017)%; and extract (1.30±0.035)%; acid-insoluble ash rate powder (2.66±0.10)%; and extract (0.87±0.031)%; extract type weight 1.01; and the physical properties of emulgel preparations were homogeneous emulgel, semisolid form, light brown color, distinctive smell of lengkuas rhizome extract, stable at 5 o C and 25 o C for 24 hours; pH 7; spreadability (2.45±0.03) g.cm.s-1; stickiness (8.80±0.72) seconds; o/w emulsion type; and viscosity (1.37±0.22) Pa.s. This study obtained extracts of lengkuas rhizomes that meet the requirements of non-specific parameter standardization in general and the formulation of lengkuas rhizome extract emulgel had good physical properties. Keywords: lengkuas rhizome extract, non-specific parameter standardization, emulgel ABSTRAK Rimpang lengkuas memiliki aktivitas sebagai antifungi. Ekstrak rimpang lengkuas perlu dilakukan standardisasi parameter non spesifik untuk memperoleh sediaan yang terjamin mutunya secara konsisten. Sediaan topikal emulgel ekstrak rimpang lengkuas merupakan sediaan yang mudah bercampur dengan zat aktif yang bersifat hidrofob atau hidrofil. Penelitian ini bertujuan untuk mendapatkan formula emulgel ekstrak rimpang lengkuas yang memiliki mutu yang baik serta sifat fisik yang baik. Ekstraksi rimpang lengkuas diperoleh dengan menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak distandardisasi dengan parameter non spesifik. Selanjutnya ekstrak diformulasikan dalam bentuk sediaan emulgel dengan konsentrasi 10%. Emulgel dievaluasi uji sifat fisik. Hasil penelitian diperoleh rendemen ekstrak (14,66±0,056)%; susut pengeringan serbuk (8,63±0,134)%; kadar air ekstrak (5±0)%; kadar abu total serbuk (3,24±0,017)%; dan ekstrak (1,30±0,035)%; kadar abu tidak larut asam serbuk (2,66±0,10)%; dan ekstrak (0,87±0,031)%; bobot jenis ekstrak 1,01; dan uji sifat fisik sediaan emulgel diperoleh emulgel homogen, bentuk semisolid, berwarna coklat muda, bau khas ekstrak rimpang lengkuas, stabil pada suhu 5 o C dan 25 o C selama 24 jam; pH 7; daya sebar (2,45±0,03) g.cm.s-1; daya lekat (8,80±0,72) detik; tipe emulsi o/w; dan viskositas (1,37±0,22) Pa.s. Penelitian ini diperoleh e...

Mulberry leaves (Morus alba L.) contain quercetin, a flavonoid compound with antibacterial activity against Staphylococcus aureus. For convenience, dosage accuracy, and hygiene, a gel formulation with a mixture of carbopol and propylene glycol is required. This study aimed to determine the right concentration of carbopol and propylene glycol to obtain a gel with good physical properties and antibacterial activity on Staphylococcus aureus. Mulberry leaf extract was obtained by maceration method. A factorial design method was used to optimize carbopol and propylene glycol concentrations. The parameters of gel physical properties were the viscosity, spreadability, adhesion, and pH test. The optimal area was determined by creating a contour plot of the parameters test result. Validation of the optimum formula was by comparing the prediction result to the actual research result. The data were analyzed using SPSS with a 95% confidence level. The results showed that the concentration of carbopol and propylene glycol was 1.04% and 7.85%, 1832.42 ± 62.48 cP viscosity, 5.96 ± 0.08 cm spreadability, 64.63 ± 0.97 seconds of adhesion, and pH 5.26 ± 0.03. The antibacterial test showed an inhibitory power with 28.67 ± 0.76 mm. From the teat result, it can be concluded that the gel had antibacterial activity and good physical properties.