The use of conventional tablets in geriatric patients is currently limited because of a decrease in their physiological functions, such as tremor and difficulty of swallowing pills, which lowers their compliance with drug therapy. Hypertension, one of the degenerative diseases suffered by geriatric patients, is treatable with atenolol tablets or capsules that are less soluble in water or, in other words, has a poor dissolution. This research attempted to improve the dissolution of atenolol by formulating it into orodispersible tablets (ODTs), and as such, the disintegration time was modified by adding co-processed crospovidone-croscarmellose sodium in 1:1 ratio. Moreover, Poloxamer ® 188 was added to the formulation of atenolol-β-cyclodextrin inclusion complex. The post-compression test revealed that ODTs disintegrated quickly within 36.67±1.21 seconds (<60 seconds) and had physical characteristics that met the pharmaceutical requirements. The amount of atenolol dissolved within 30 minutes in the dissolution study was 84.39% (%Q 30 minutes ). The results of the accelerated stability study (at 40 °C and RH 75±5 %) for two weeks proved that the physical and chemical characteristics of the produced orodispersible atenolol tablets were stable. 284 The use of conventional tablets today raises problems in geriatric patients, especially who receive long-term therapy for degenerative diseases. Patients in this age group show changes in their physiological conditions that often lead to tremor, difficulty in chewing and swallowing, and proneness to choking (Dashora, 2013). An example of degenerative diseases is hypertension (Dipiro, 2008). Atenolol is a hypertension drug that is rather difficult to dissolve in water and has low dissolution. Dissolution is a process preceding the absorption of drug substances after which the drug can provide the desired pharmacological effect for a particular time (Qiu et al., 2009). Dissolution can be improved by modifying the physical features of the drug using specific materials to form molecular complexes (Shargel and Yu, 2017). An example of these materials is β-cyclodextrin. The outer part of β-cyclodextrin is hydrophilic, while the interior is hydrophobic (Vivek et al., 2012;Sinko, 2011). Previous research has proven how the formation of inclusion complexes can increase the dissolution of water-insoluble drugs, such as rosuvastatin. Rosuvastatin reacts to the addition of β-cyclodextrin, and in rosuvastatin-β-cyclodextrin inclusion complex, the crystallinity of this drug decreases (Akbari et al., 2011). Based on this result, the formation of atenolol-β-cyclodextrin inclusion complex is assumed to be able to increase the dissolution of atenolol.Another strategy to improve the dissolution of atenolol is by formulating orodispersible dosage forms. Orodispersible tablets break down or dissolve quickly in the mouth without water or chewing. U.S. Food and Drug Administration defines them as tablets that can disintegrate in the oral cavity in less than 60 seconds (FDA, 2008). One way to im...