L-carnitine is a multi-functional nutrient which plays a leading role in fatty acid metabolism in mammals and other eukaryotes. Its main physiological function is to promote fatty acid b-oxidation to produce energy, which reduces body fat content and improves body weight without affecting moisture content in whole body and muscle. In recent years, its dietary supplementation in aquaculture nutrition has been studied in different cultured species. It has been proved that L-carnitine can improve growth and increase lipid utilization rate in some aquatic animals. However, such beneficial effects of dietary L-carnitine are limited or absent in other species. The reasons for the conflicting results obtained on L-carnitine functions in aquatic animals need to be elucidated. This review explores comprehensively the different physiological functions of L-carnitine in various aquatic animals. In the end, research strategies are provided to elucidate the existing conflicts on dietary L-carnitine application in aquaculture nutrition in order to promote its utilization in aquatic feed industry.

Biodegradable magnesium-based scaffolds present outstanding potential to revolutionize the treatment of coronary artery diseases, in which full recovery of arteries without long-term irritation of implants is anticipated for averting adverse events associated with the permanent stents. However, overfast degradation of magnesium (Mg) alloys obstructs their extensive applications in terms of early structural failure and impaired biocompatibility. Herein, a facile copper-incorporated coating system through nonaqueous phase synthesis of polydopamine is developed to facilitate Cu(II) capture along with robust film deposited on easily corrodible Mg, which subsequently enables sustained Cu(II) elution. It remarkably enhances corrosion resistance and impedes Mg degradation, which also contributes to improved, superior cytocompatibility, and abolished hemolysis. Moreover, through simultaneous control of Cu(II) and Mg(II) release to modulate the local microenvironment, a synergistic biochemical effect on desirable vascular cell selectivity is triggered for boosted endothelial cell viability and suppressed smooth muscle cell. Stent implantation into rabbit abdominal aorta thus exhibits accelerated re-endothelialization completed in a week, and enhanced biological outcomes, alleviated complications and prolonged structural durability in 3-month follow-up. Collectively, this study opens up an alternative route of deploying a multifunctional surface modification strategy tailoring active interplay with the Mg matrix for better outcomes of next-generation bio resorbable vascular stents.

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Next‐Generation Biodegradable Vascular Stents In article number 2205634, Jia Pei, Guang‐Yin Yuan, Jin‐Yun Tan and co‐workers report a copper‐incorporated, catechol‐based coating system on biodegradable magnesium‐alloy vascular stents to achieve reinforced stent structural durability, meanwhile, allowing for controlled local release of Mg(II) and Cu(II) to trigger synergistic bioeffect on rapid re‐endothelialization and alleviated neointima hyperplasia, bringing one step closer to the deployment of next‐generation biodegradable stents.

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