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The effectiveness of entrepreneurial leadership (EL) at different levels has been widely recognized by scholars who have carried out substantial exploration; however, the empirical studies on the effectiveness of EL are scattered and their results are mixed. This study aims to organize these findings, advance knowledge about the multilevel effectiveness of EL and clarify the heterogeneity in the relationship between EL and effectiveness outcomes. Based on a systematic review of the extant literature and the construction of an integrated framework, this study examines the influence of EL on effectiveness outcomes at multiple levels and the moderators of this relationship through meta-analysis of 35 empirical studies including 35 independent samples. The results show that EL can improve effectiveness outcomes at different levels of organization, team and individual; cultural context obviously moderates this relationship, whereas the moderating effects of enterprise type and EL measure are all not significant. This study helps to determine the specific association of EL with effectiveness outcomes at different levels, and identify important factors influencing this relationship, which broadens the understanding of leadership effectiveness and provides certain value for enterprises to give full play to the role of EL at all levels.

Vitreoscilla hemoglobin (VHb), the first discovered bacterial hemoglobin, is a soluble heme-binding protein with a faster rate of oxygen dissociation. Since it can enhance cell growth, product synthesis and stress tolerance, VHb has been widely applied in the field of metabolic engineering for microorganisms, plants, and animals. Especially under oxygen-limited conditions, VHb can interact with terminal oxidase to deliver enough oxygen to achieve high-cell-density fermentation. In recent years, with the development of bioinformatics and synthetic biology, several novel physicochemical properties and metabolic regulatory effects of VHb have been discovered and numerous strategies have been utilized to enhance the expression level of VHb in various hosts, which greatly promotes its applications in biotechnology. Thus, in this review, the new information regarding structure, function and expressional tactics for VHb is summarized to understand its latest applications and pave a new way for the future improvement of biosynthesis for other products.

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PurposeThis study aims to investigate the multiple influence paths or underlying mechanisms of entrepreneurial leadership (EL) on adaptive innovation from the perspectives of organizational learning and resource management, drawing on complex adaptive system theory.Design/methodology/approachWith a questionnaire survey of 317 senior and middle managers from different firms in China, structural equation modeling was used to test the hypothesized conceptual model, and bootstrapping method was employed to examine the multiple mediating effects.FindingsResults indicate that EL has a significant and positive effect on adaptive innovation. This relationship is partially mediated through exploitative learning, exploratory learning, resource bricolage and boundary-spanning integration, respectively. The impact of EL on adaptive innovation is also sequentially transmitted through exploitative learning and resource bricolage or exploratory learning and boundary-spanning integration.Originality/valueAdaptive innovation has become a firm competition strategy to cope with dynamic changes in current uncertain environment where EL can play its effectiveness to engage firms in such innovation activities. However, the question of why and how EL drives adaptive innovation has yet to be discussed. This study highlights the innovation effectiveness of EL and the triggering process of adaptive innovation, and contributes to several countermeasures for firms to implement leadership and innovation practices responding to uncertain environment.