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Gout is a disease involving abnormal purine metabolism that is widespread in mammals and birds. Goose is especially susceptible for gout in early stage. However, a few studies investigated the ontogenetic pattern of goslings with purine metabolic abnormality. Our studies were conducted to investigate whether persistent purine metabolic abnormality would lead to aggravation of visceral inflammation and intestinal microbiota dysbiosis in goose. A total of 132 1-day-old Magang geese were randomly divided into six replicates and fed a high-calcium and protein meal-based diet from 1 to 28 days. The experiment lasted for 28 days. Liver and kidney damages were observed in 14- and 28-day-old Magang geese, and liver inflammation increased with increasing age. In 28-day-old Magang geese, serum CAT and liver GSH-Px activity were significantly reduced. Furthermore, jejunum intestinal barrier was impaired and the abundance of Bacteroides was significantly reduced at the genus level. Collectively, the high-calcium and high-protein (HCP) meal-based diet caused liver and kidney damage in 28-day-old Magang geese, leading to hyperuricemia and gout symptoms, and the intestinal barrier is impaired and the intestinal flora is disrupted.

Background:The uterus is prone to many diseases, including endometriosis. Transvaginal ultrasonography (TVS) has become a frequently used detection method for deep invasive endometriosis (DIE). Methods:The combinations of relevant keywords and medical topic title terms were searched in the databases of PubMed, Medline, and Embase, and the Cochrane Central Register of Controlled Trials (endometriosis) from their inception to June 2021. Based on the descriptive terms of endometriosis, deep infiltrating endometrium, heterotopia, deep endometriosis, ultrasound, and TVS, the full texts of the target articles were obtained and subjected to a manual search. Meta-analysis was performed using RevMan 5.3 software provided by the Cochrane collaboration.Results: A total of 12 articles were included in this study, involving 1,707 patients overall. The sensitivity range was 0.57 to 0.98, and the specificity range was 0.87 to 1.00. The positive likelihood ratio (PLR) was 6.2282 [95% confidence interval (CI): 3.774 to 8.932]; the negative likelihood ratio (NLR) was 0.0664 (95% CI: 0.03 to 0.09); and the duration of remission was 1,174.7 (95% CI: 683.8 to 1,793.4). The sensitivity, specificity, PLR, NLR, and diagnostic odds ratio (DOR) of χ 2 were 36.10 (P=0.021), 27.00 (P=0.035), 53.11 (P=0.001), 55.22 (P=0.001), and 63.89 (P=0.001), respectively, and the differences were statistically significant.Discussion: A total of 12 articles were included in this meta-analysis, and the results were basically stable.Diagnosis with TVS showed high sensitivity (98%) and specificity (nearly 100%), indicating that it is a reasonable detection method for DIE, improving the disease status of patients.

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