An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines. This route features unprecedented fast reaction rate with full conversion reached within 10 min...

A convergent access to substituted 2-iminoimidazolidines from aromatic amines and N-propargyl S-methylthiourea is developed via Ag­(I)-mediated cascade guanylation–cyclization reactions. This method features high regioselectivity, excellent efficiency, and mild reaction conditions. Subsequent deprotection of the Boc (tert-butyloxycarbonyl) group under acidic conditions provides expedient access to aryl 2-aminoimidazole derivatives in a convenient manner.

Efficient access to S-methyl dithiocarbamates was reached with sulfonium or sulfoxonium iodide as methylation reagent. This method is reliable for the synthesis of dithiocarbamates from primary or secondary amines, with...

Inspired by aldol sensors, a novel series of fluorescent probes were developed for measuring and capturing protein citrullination.

S-Adenosyl-L-homocysteine (SAH) is a universal byproduct and product inhibitor of methyltransferase-catalyzed methylation reaction. Here based on ReACT (Redox-Activated Chemical Tagging) chemistry, direct derivatization and fluorescent measurement of SAH were achieved...