Congenital heart disease (CHD) is a common structural birth defect worldwide, and defects typically occur in the walls and valves of the heart or enlarged blood vessels. Chromosomal abnormalities and genetic mutations only account for a small portion of the pathogenic mechanisms of CHD, and the etiology of most cases remains unknown. The role of epigenetics in various diseases, including CHD, has attracted increased attention. The contributions of DNA methylation, one of the most important epigenetic modifications, to CHD have not been illuminated. Increasing evidence suggests that aberrant DNA methylation is related to CHD. Here, we briefly introduce DNA methylation and CHD and then review the DNA methylation profiles during cardiac development and in CHD, abnormalities in maternal genome-wide DNA methylation patterns are also described. Whole genome methylation profile and important differentially methylated genes identified in recent years are summarized and clustered according to the sample type and methodologies. Finally, we discuss the novel technology for and prospects of CHD-related DNA methylation.

A novel dual band-notched CPW-fed UWB MIMO antenna with mutual coupling reduction characteristics is presented in this paper. The proposed antenna uses CPW feeding to expand the antenna bandwidth. The measured impedance bandwidth with S 11 < −10 dB is 137% from 3 GHz to 16 GHz. The overall size of the antenna is 46 mm × 32 mm × 1.6 mm. In order to achieve dual bandnotched characteristics, a cup-shaped branch is added to the grounding plate, and a step impedance resonator (SIR) is added to the microstrip line. By adding periodic strip branches on the back of the antenna, the mutual coupling between the two antennas is significantly reduced, which meets the requirements of practical applications. In addition, the proposed antenna has a compact size and can provide a stable radiation pattern, which is suitable for UWB communication systems.

In this paper, we give a direct construction for gregular cyclic difference packings CDP(6, 1; gp)'s by utilizing Weil's theorem on character sum estimates over GF(p) with prime congruent to 7 modulo 12 and greater than 7, where g = 15, 20. As its application, we obtain a new class of optimal (gv, 6, 1) optical orthogonal codes with v a product of primes congruent to 7 modulo 12 and greater than 7 and g = 15, 20, 105, 140. key words: Optimal optical orthogonal code, Regular cyclic difference packing.

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