The present study investigated the effects of andrographolide on postoperative cognitive dysfunction (POCD) in aged rats to gain insight of the underlying mechanism, which may provide theoretical basis for the clinical application of andrographolide to prevent POCD in older patients. Thirty aged male rats were randomly assigned to 3 groups: Control, model and andrographolide groups. The Morris water maze test was used to examine the spatial memory and learning ability of the rats postoperatively. The histological alterations of neuronal cells in the hippocampus were visualized by H&E staining. The serum levels of neuron-specific enolase (NSE), human soluble protein-100β (S-100β) and the inflammation factors of interluekin (IL)-1β, IL-6 and TNF-α involved in the nuclear factor κB (NF-κB)/mitogen-activated protein kinase (MAPK) signaling pathway were detected by ELISA. The NF-κB/MAPK signaling pathway-associated proteins in rat serum were detected by western blotting. Following andrographolide treatment, the rats significantly gained learning ability after surgery. Is it ameliorated hippocampal neuronal injury in rats following surgery. Andrographolide decreased NSE, S-100β, and the inflammation factors, IL-6, IL-1β and TNF-α in serum. Andrographolide reduced NF-κB/MAPK pathway-associated protein expression. Andrographolide ameliorated POCD in aged rats following surgery. The underlying mechanism may be associated with the downregulation the inflammatory factors and NF-κB/MAPK-associated protein expression.
Based on frequently used internal partitions in offices, the effects of pollutant source characteristics and an internal partition on airflow and contaminant distribution under different ventilation modes are studied in this paper. The indoor flow field measurement is implemented in a 1:1 single environmental chamber under different ventilation patterns, and then the numerical model is established. The numerical method is verified and analyzed by comparing the measured and simulated results. According to the verification results, the numerical simulation is introduced to study the influence of different supply and return air mixes and pollutant source distributions on the flow field and diffusion performance with an internal partition. The indoor flow field and concentration distribution under different conditions are compared, and the discharge efficiency under different working conditions is analyzed. The results indicate that internal partitions have a greater influence on the down-supply up-return ventilation mode than the floor-supply up-return and top-supply down-return ventilation mode. Furthermore, if the room is zoned, the effect of source position is larger under the down-supply up-return ventilation mode than under the other two modes.
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