Agriculture is an important activity globally since it ensures food security and is a source of income for many families, especially those living in underprivileged countries. The continuous growth in the global population has seen farmers increase the crop production acreage to meet the increasing demand for food and avert food shortage. Despite this, farmers continue to harvest lower yields than anticipated, which threatens global food security. The reduced yields result from outdated and ineffective farming practices as well as pests and diseases. Diseases are a significant cause of reduced crop yields globally. Biotic and abiotic factors cause diseases. Of the recognized biotic causes of disease, root-knot nematodes, also known as Meloidogyne spp. are plant-parasitic nematodes that cause significant losses to farmers in terms of reduced plant yields. Over the years, researchers have conducted several studies on the effective use of Trichoderma spp. fungi as a biocontrol agent for these pathogens. This paper analyzes the advancements made towards the effective and efficient biocontrol of Meloidogyne spp. using Trichoderma spp. and the implications of these advancements for agriculture and food security.