Most dangerous and prevalent form of malaria is caused by the Plasmodium falciparum mediated malaria and poses the greatest threat to the humans. Emergence of multi drug resistant parasite hindered the prevention of malaria burden worldwide. This study is mainly focused on the erythrocytic membrane stabilisation using regionally available medicinal plant extracts and its corelation with the oxidative stress generated during the intracellular erythrocytic stages development of Plasmodia. The results disclosed that antioxidant potential of the medicinal plants can diminish the reactive oxygen species generation leads to restrict the plasmodial invasion into erythrocytes ultimately decreases the parasitic load. Hence, the evidence of the effective phytochemicals present in the selected medicinal plants can be the promising anti-plasmodial drug candidates as a future perspective.