No abstract

A scalable electrochemical difunctionalization of gem-difluoroalkenes to structurally versatile difluoro motifs was achieved. This methodology features reagent-free conditions, good functional group tolerance, and a relatively broad substrate scope. Meanwhile, the electrolysis protocol is easy to handle, and the products show good regio-and chemoselectivity. The reaction mechanism was also preliminarily studied.

A general and practical protocol for electrochemisty-controlled dearomative 2,3-difunctionalization of indoles via electrochemically anode-selective oxidative cross coupling has been demonstrated. The reaction runs under metal, oxidant and catalyst free condition,...