The development of wireless communication and the Internet of Things has promoted the construction of smart cities and is the technical basis for the construction of smart cities. The influence of regional economic development level on smart city construction cannot be ignored, and it constitutes the external environment of smart city construction. The combination of the two will play a driving role in the construction of smart cities. Therefore, the planning and construction of smart cities must be coordinated with the realization of the two. This paper adopts a combination of literature analysis and field investigation to analyze the decoupling between smart city construction and regional economic development, conduct research on relevant cities, and combine the current situation of smart city construction to collect the problems encountered in smart city construction and regional economic development. Through analysis, it provides suggestions for the development of smart cities and regional economic development. The survey results show that in the process of smart city construction and regional industrial economic development in the context of the Internet of Things, information security and lack of talent are the most prominent problems. Among the relevant suggestions on these issues, the proportion of talent introduction is about 45%, and the proportion of rational planning of industrial structure is about 28%. Based on the experience of existing research results, this study uses optimization algorithms to make the impact of various factors more specific, which is helpful for each region to make scientific planning based on its own actual situation.