No abstract

Tamsin Ford was supported by a Wellcome Clinical Training Fellowship in Health Services Research while completing this work.

Parietal gray matter loss may contribute to the onset of schizophrenia while orbitofrontal gray matter loss is associated with illness duration.

General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms AbstractObjective: We aimed to describe the prevalence and age distribution of personality disorders (PDs) and their comorbidity with other psychiatric disorders in an age-stratified sample of Australian women aged ≥25 years. Individual PDs (paranoid, schizoid, schizotypal, histrionic, narcissistic, borderline, antisocial, avoidant, dependent, obsessive-compulsive), and lifetime mood, anxiety, eating, and substance misuse disorders were diagnosed utilizing validated semi-structured clinical interviews (SCID-I and SCID-II). The prevalence of PDs and Clusters were determined from 3 the study population (n=768), and standardised to the Australian population using the 2011 Methods:Australian Bureau of Statistics census data. Prevalence by age and the association with mood, anxiety, eating and substance misuse disorders was also examined. Results:The overall prevalence of PDs in women was 21.8% (95%C18.7, 24.9). Cluster C PDs (17.5%, 95%CI 16.0, 18.9) were more common than Cluster A (5.3%, 95%CI 3.5, 7.0)and Cluster B PDs (3.2%, 95%CI 1.8, 4.6 Conclusions: Approximately one in five women were identified with a PD, emphasising that PDs are relatively common in the population. A more thorough understanding of the distribution of PDs and psychiatric comorbidity in the general population is crucial to assist allocation of health care resources to individuals living with these disorders.