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[reaction: see text] A stepwise [3+3] annelation sequence to tetrahydropyridines via addition of the Büchi Grignard to aziridines has been developed. These intermediates can be further functionalized with good regio- and stereocontrol and this methodology has been employed in the stereoselective formal synthesis of (-)-dihydropinidine.

Pyridine derivatives R 0380 A [3 + 3] Annelation Approach toTetrahydropyridines. -The stepwise protocol proceeds via addition of the Buechi-Grignard to aziridines. The method is applied to the synthesis of the alkaloid (-)-dihydropinidine (XIII). -(PATTENDEN, L. C.; WYBROW, R. A. J.; SMITH, S. A.; HARRITY*, J. P. A.; Org. Lett. 8 (2006) 14, 3089-3091; Dep. Chem., Univ. Sheffield, Sheffield S3 7HF, UK; Eng.) -R. Steudel 46-182