Purpose: While the co-morbidity of symptoms associated with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) in the injured military population is currently being discussed and researched, those of us in the rehabilitation fields need to be ready now to serve this complex population. We are challenged to provide the best services with limited research and evidence-based practices to guide us. This article presents an interdisciplinary approach to treatment for soldiers with TBI. Method: We compare and contrast the blast-induced brain injury acquired in the military population, designated as the “signature injury of this war,” to “typical” TBI populations. Results and conclusions: We share what we have learned by serving this population and present each discipline's assessments, treatment strategies, outcome measures, and suggestions for navigating the military “mindset” of the soldiers being served.