Schiff base N4O2 complexes offer a flexible template on which to develop novel antimalarial drug complexes that inhibit the aggregation of hemozoin, a detoxification product of the malaria parasite Plasmodium falciparum. The efficacies of these complexes are dependent on the charges of the complexes. Further evidence suggests that these complexes inhibit hemozoin formation via a specific drug/heme propionate salt that prevents the formation of the requisite axial propionato linkage in the repeating dimeric unit of the hemozoin aggregate.

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Improved autoregulation was associated with PRx values near zero. Controlling those parameters that affect PRx, namely MAP, ICP and CPP and more importantly cerebral oxygen perfusion (COP), would likely increase the probability of a better outcome while guarding against secondary insult.

A novel target for the development of new antimalarial treatments is the detoxification pathway of free heme released during the catabolism of host Hb in the digestive vacuole of the malaria parasite Plasmodium falciparum. We have synthesized and examined two peptide dendrimers (BNT I and II) based on the tandem repeat motif of the histidine rich protein II (HRP II) from P. falciparum for their abilities to both bind heme substrates and to form the critical detoxification aggregate hemozoin. Each template was capable of binding significant amounts of the natural substrate Fe (III)PPIX along with alternate substrates such as Zn (II)PPIX and the metal free protoporphyrin IX. Further, it has been demonstrated that the dendrimeric biomineralization templates were capable of supporting the aggregation of hemozoin. New applications of this template for drug screening as well as the elucidation of antimalarial drug mechanisms are discussed.