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H epatitis E virus (HEV) is a small, nonenveloped RNA virus belonging to the family Hepeviridae, genus Orthohepevirus. HEV genotypes 3 and 4 cause zoonotic infections described in countries in Europe and transmitted mostly by the fecal-oral route in contaminated food or the environment (1). Hepatitis E

Plasma exchange, including with pathogen-reduced plasma, is a risk factor for posttransplantation HEV infection and transaminase elevation. Screening for HEV RNA should be carried out in kidney transplant recipients treated with plasma exchange.