Background. Sudden deafness is an emergency in the Ear Nose Throat Department, a subset of sensorineural hearing loss within a 72-hour window period and consists of a decrease in hearing of 30 decibels affecting at least three consecutive frequencies. The therapy given is corticosteroids, systemic corticosteroids or intratympanic corticosteroids injection, or both. The prognosis of sudden deafness depends on several factors. Patient with sudden hearing loss does not always have the same result in hearing improvement. This study was aimed to determine the factors that affect the results of intratympanic corticosteroid injection therapy in patients with sudden deafness.Methods. This study is an observational study with a cross-sectional design. The data were collected using medical records on 96 ears given intratympanic corticosteroid injection therapy at Dr. Mohammad Hoesin Hospital Palembang from July 2018 to February 2021.Results. From 96 ears conducted in the study, the improvement of therapeutic results on intratympanic corticosteroid injection in patients with sudden deafness was 72.9%. The study found factors that influenced the outcome of therapy, namely age (p=0.002), the onset of therapy (p = 0.003), and the use of a combination of systemic steroids (p=0.010). From the logistic regression test, it was found that the factors that most influenced the results of intratympanic corticosteroid injection therapy were young age 18-40 years (p=0.016) with (OR) 6.654 (CI95% 1.418-31.222) and therapy onset less than two weeks (p=0.027) with (OR) 3.108 (95% CI 1.134-8.515).Conclusions. The factors associated with the improvement in the outcome of intratympanic corticosteroid injection therapy in patients with sudden hearing loss were patient age and early onset of therapy.

Tuli mendadak merupakan tuli sensorineural yang termasuk dalam kedaruratan neurotologi. Tuli mendadak adalah penurunan pendengaran sensorineural 30 dB atau lebih, paling sedikit tiga frekuensi berturut-turut dan berlangsung dalam waktu kurang dari 72 jam. Diagnosis tuli mendadak ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan fungsi pendengaran dan pemeriksaan penunjang untuk mencari etiologi yang mendasari terjadinya tuli mendadak. Penatalaksaan kasus tuli mendadak sebaiknya diterapi berdasarkan etiologi yang mendasarinya. Namun hampir sebagian kasus tuli mendadak bersifat idiopatik. Salah satu terapi tuli mendadak adalah dengan pemberian kortikosteroid. Kortikosteroid dapat diberikan secara sistemik maupun injeksi intratimpani. Pemberian kortikosteroid melalui intratimpani dapat sebagai terapi awal, kombinasi dengan terapi lain atau sebagai terapi penyelamatan (salvage therapy). Injeksi kortikosteroid intratimpani dapat menjadi alternatif pada penanganan tuli mendadak, khususnya jika terapi sistemik gagal. Injeksi intratimpani juga memiliki keuntungan yaitu konsentrasi obat yang tinggi bila diberikan langsung ke telinga yang terkena atau untuk menghindari efek samping steroid sistemik dan dapat diberikan pada pasien dimana kortikosteroid sistemik kontraindikasi untuk diberikan.

Background. Sudden deafness is an emergency in the Ear Nose Throat Department, a subset of sensorineural hearing loss within a 72-hour window period and consists of a decrease in hearing of 30 decibels affecting at least three consecutive frequencies. The therapy given is corticosteroids, systemic corticosteroids or intratympanic corticosteroids injection, or both. The prognosis of sudden deafness depends on several factors. Patient with sudden hearing loss does not always have the same result in hearing improvement. This study was aimed to determine the factors that affect the results of intratympanic corticosteroid injection therapy in patients with sudden deafness.Methods. This study is an observational study with a cross-sectional design. The data were collected using medical records on 96 ears given intratympanic corticosteroid injection therapy at Dr. Mohammad Hoesin Hospital Palembang from July 2018 to February 2021.Results. From 96 ears conducted in the study, the improvement of therapeutic results on intratympanic corticosteroid injection in patients with sudden deafness was 72.9%. The study found factors that influenced the outcome of therapy, namely age (p=0.002), the onset of therapy (p = 0.003), and the use of a combination of systemic steroids (p=0.010). From the logistic regression test, it was found that the factors that most influenced the results of intratympanic corticosteroid injection therapy were young age 18-40 years (p=0.016) with (OR) 6.654 (CI95% 1.418-31.222) and therapy onset less than two weeks (p=0.027) with (OR) 3.108 (95% CI 1.134-8.515).Conclusions. The factors associated with the improvement in the outcome of intratympanic corticosteroid injection therapy in patients with sudden hearing loss were patient age and early onset of therapy.

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