No abstract

Hypoxia is a key impediment encountered in the treatment of most solid tumors, leading to immune escape and therapeutic resistance. Perfluorocarbons (PFCs) have a unique electrical structure and are characterized by a high solubility for gases. PFC-based oxygen carriers have been evaluated for their ability to deliver oxygen effectively to hypoxic tissues, and significant clinical translation has been demonstrated. And due to the unique acoustic activity, PFCs have been employed to stabilize the injection of gas microbubbles (MBs) as clinical ultrasonography contrast agents. In contrast, the ultrasound and photothermally activatable PFC phase-shift nanodroplets (P-SNDs) represent a novel alternative to ultrasound imaging and hypoxia improvement. The PFC-based oxygen carriers may be utilized to improve the efficacy of cancer treatments based on synergistic radiotherapy (RT), chemotherapy (CMT), and photodynamic therapy (PDT) to reshape the tumor microenvironment through synergistic immunotherapy (IMT) and to achieve precise tumor diagnosis using acoustic imaging. This review described the characteristics of PFCs to provide an update on the design of PFC delivery systems used for oxygen delivery and ultrasound imaging to facilitate the treatment and diagnosis of tumors. The objective was to contribute to overcoming the obstacles encountered during PFC research and provide the developing prospects.

In this paper, a floating electrode employed to generate a stable large-area diffuse discharge plasma under an open oxygen-rich environment. The discharge image and the optical emission spectra of the N2(C-B), N2 +(B-X), N2(B-A), and O(3p-3s, 777 nm) are measured to analyze the morphological and optical characteristics of the discharge. The effects of applied voltage, gas flow rate, and electrode gap on the reactive species, vibrational temperature and rotational temperature are investigated, as well as the discharge mode is discussed by simulating the electrostatic field before the breakdown. It is found that the change of applied voltage and electrode gap causes the transition of the discharge modes among corona mode, diffuse discharge mode and spark mode. It shows that the floating electrode can inhibit the transition from discharge to spark mode to a certain extent, which is conducive to maintaining the stability of discharge. As is vividly illustrated in this study, the increase of applied voltage or the decreasing of electrode gap contributes to the generation of more active particles, such as N2(C) and N2 +(B). Furthermore, the Joule heating effect becomes more evident with the increased applied voltage when the electrode gap is 15 mm and 20 mm. Moreover, as the applied voltage increases, the vibrational temperature increases at the electrode gap of 25 mm.

Arsenic trioxide (ATO) combined with all trans retinoic acid (ATRA) is the first choice for the treatment of low and medium risk acute promyelocytic leukemia (APL). Clinical studies reported that the combination of ATO and ATRA could achieve a significant curative effect. However, the retinoic acid syndrome, serious drug resistance and the short half-life in vivo which lead to frequent and large dose administration limit the application of ATRA. In addition, the preparations of arsenic are conventional injections and tablets in clinic, which has poor patients' compliance caused by frequent long-term administration and serious side effects. In order to overcome the above limitations, a phospholipid phase separation gel (PPSG) loaded with ATO and ATRA was developed. ATO+ATRA-PPSG (AAP), as a biodegradable sustained-release delivery system, was the first achievement of co-delivery of hydrophilic ATO and lipophilic ATRA with high drug loading which is the main problem in the application of nano preparation. The prepared PPSG displayed high safety and biocompatibility. The drug in PPSG was released slowly and continuously in vivo and in vitro for up to 10 d, which could reduce the side effects caused by the fluctuation of blood drug concentration and solve the problem of the long treatment cycle and frequent administration. In vivo pharmacokinetics depicted that PPSG could improve the bioavailability, decrease the peak concentration, and prolong the t 1/2 of ATO and ATRA. Particularly, AAP significantly inhibited the tumor volume, extended the survival period of tumor-bearing mice, and promoted the differentiation of APL cells into normal cells. Therefore, ATO+ATRA-PPSG not only could co-load hydrophilic ATO and lipophilic ATRA according to the clinical dosage, but also possessed the sustained-release and long-acting treatment effect which was expected to reduce administration time and ameliorate compliance of patients. Thus, it had great potential for clinical transformation and application.

The torque ripple of a switched reluctance motor (SRM) limits its application in electric vehicles. This paper proposes a DITC system for SRMs based on a novel multilevel converter (MLC), which aims at the problem that the torque ripple cannot be effectively suppressed for the conventional direct instantaneous torque control (DITC) of an SRM due to the limitation of the DC bus voltage in the asymmetric half-bridge converter (AHBC) and the single control strategy formulated in the commutation region. Based on the advantages of fast excitation and fast demagnetization for the proposed MLC and the torque distribution characteristics for each phase winding in the commutation region, a novel torque hysteresis control strategy is developed to improve the torque-following ability of the DITC and achieve the purpose of minimizing the torque ripple in the commutation region. In addition, multiobjective optimization control of the motor is carried out to improve the efficiency of the DITC system while suppressing the torque ripple. The effectiveness of the proposed SRM drive scheme is verified by experiment, which is of great significance for the application of SRMs in electric vehicles.