Objective of the study: This research aims to explore the diverse impacts of national innovation systems of BRICS countries by indicating the key elements and systems aspect, how these aspects have committed to the running of the whole systems and interpreted inside the economic development of these nations.Methodology/approach: Data were collected from the World Bank (WDI), United Nations Educational, Scientific and Cultural Organization (UNESCO), United State Patent and Trade office (USPTO), and World Intellectual Property Organization (WIPO) for Brazil, Russia, India, China and South Africa (BRICS) countries. Data used for following research are time series, annual data from 1999-2014. The multi-regression analysis was completed with utilizing the Statistical package for the Social Science (SPSS).Originality/Relevance: We intend at devoting to the research literature and policy by producing quantitative based proof of the framework that connects the comprehensive element of innovation system to economic system for a longtime.Main results: The findings showed the degree to which components of the National innovation system (NIS), depend on one another for Brazil, Russia, India, China and South Africa (BRICS) , in this regard, any changes in one indicator can effect on other indicators in the system.Theoretical/methodological contributions: Our research is based on the conceptual analyses which draw from the existing literature. It is based on a model to evaluate the dynamics of innovation capacity, absorptive capacity impact and robustness of the economic development.Social /management contributions: Our results have significant implication for policy makers.