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Objective: To evaluate the effect of multidisciplinary collaborative care (MCC) in patients with both acute coronary syndrome (ACS) and depression and/or anxiety disorders compared with usual physician care (UPC). Methods: Depression and/or anxiety were screened by using SDS and SAS, ACS patients with depression and/or anxiety disorders were randomized into MCC and UPC groups. The cardiac outcomes and the life quality were evaluated at 1 year follow-up. Results: Overall, 30.19% (96/318) patients had positive screen results. At 1 year, Cardiac outcome measures for patients in MCC group were significantly better for composite events of cardiac death and non-fatal MI (6.12% vs 23.40%, p=0.016), cardiac function (NYHA functional classification III or IV, 0% vs 25%, p=0.05), and angina pectoris (21.28% vs 85%, p<0.0005), than patients in UPC group; the life quality were improved in patients in MCC group. Conclusion: After ACS, 30.19% of patients had depression and/or anxiety disorders, MCC had better effects on cardiac outcomes and quality of life in ACS patients with Psychiatric disorders.

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