Neurologic disorders impact the ability of the brain to generate sleep, wake, and circadian functions. Preexisting or de novo sleep-wake-circadian pathologies are generally underdiagnosed in neurologic patients despite their major impact on onset, evolution, and outcome of neurologic disorders. Neurologic disorders are frequently accompanied by sleep-wake EEG changes. Extensive brain damage can lead to the absence of measurable differentiation between sleep and wakefulness (status dissociatus). New technologies will facilitate early detection and (long-term) monitoring of neurologic patients and the optimization of their clinical management.

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Post-COVID-19 syndrome is an ongoing challenge for healthcare systems as well as for society. The clinical picture of post-COVID-19 syndrome is heterogeneous, including fatigue, sleep disturbances, pain, hair loss, and gastrointestinal symptoms such as chronic diarrhea. Neurological complaints such as fatigue, cognitive impairment, and sleep disturbances are common. Due to the short timeframe of experience and small amount of evidence in this field, the treatment of post-COVID-19 syndrome remains a challenge. Currently, therapeutic options for post-COVID-19 syndrome are limited to non-pharmaceutical interventions and the symptomatic therapy of respective symptoms. In this article, we summarize the current knowledge about therapeutic options for the treatment of neurological symptoms of post-COVID-19 syndrome.

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