The current frame of reference on adherence to pharmacotherapy includes a set of behaviors experienced by the user, with observation of the detailed and continuous history of the use of each dose of the medication. Indicators based on pharmacy records have been used to measure adherence. The current review aimed to identify and describe indicators based on pharmacy records and to discuss their adequacy and limitations for measuring adherence. An exploratory literature review was conducted in three databases using the terms "adherence", "pharmacy records/administrative data", and "measure" to compose the descriptors for the selection of 81 articles and the elaboration of a chart with the denomination, sources, methods for calculation, description, and interpretation of the operational and referential meaning of 14 indicators. Given the most recent taxonomy for adherence proposed in the literature, we concluded that the indicators can be useful for identifying patients with medication-seeking behavior-related problems and analysis of persistence. The distance between supply-related events and difficulties in treatment follow-up can influence an analysis based exclusively on the use of these indicators.

Resumo O tratamento da aids implica a utilização de diversos medicamentos que compõem a terapia antirretroviral, sendo o controle logístico monitorado por um sistema nacional informatizado de dispensação, o Sistema de Controle Logístico de Medicamentos (SICLOM). O objetivo foi investigar a utilização da terapia antirretroviral de pacientes de dois hospitais universitários no Estado do Rio de Janeiro a partir do SICLOM. Foi realizado um estudo seccional com coleta de dados sociodemográficos e de dispensação, a partir do SICLOM. A avaliação da posse para estimativa de pacientes não aderidos foi realizada através do indicador de proporção de dias cobertos (PDC). Foram incluídos 538 pacientes com cadastro ativo no SICLOM, maiores de 18 anos de ambos os sexos. O ARV mais utilizado em ambos os hospitais foi lamivudina, dentre 58 esquemas diferentes identificados. A maior parte dos pacientes utilizava esquemas classificados como de primeira linha de tratamento. Em média, a proporção de dias cobertos (posse) pelo tratamento foi 88% (± 0,16). A linha de tratamento mostrou associação estatística com a posse, sendo observado melhor PDC 91% (p < 0,001) para os esquemas resgate. Este estudo corroborou o SICLOM como uma boa fonte para conhecimento do perfil de utilização de ARV.

Objective: The aim of this work was to evaluate the impact of an integrative activity based on clinical practices in disciplines of the basic and health care curriculum of an undergraduate pharmacy school. Methods: We developed an applied an interdisciplinary methodology in basic and health care disciplines focused on hospital pharmacy practice, including Pharmacokinetics and Pharmacodynamics; Hospital Pharmacy; Pharmacology I; Pharmacology II; Toxicology; Clinical Pharmacy. The methodology used was constructed on problem-based learning (PBL) focused on the health policies integrated into pharmaceutical clinical practices. Students were encouraged to formulate hypotheses, plan experiments and to discuss their outcomes. The evaluation of the effectiveness of the methodology was performed by analyzing the following parameters: escaping of discipline and measurement of students' performance improvement. Results: We noted that students were able to reformulate their original perceptions immediately after teaching. The students significantly reduced the avoidance of Pharmacology I; Pharmacology II; Toxicology. Furthermore, the students significantly improved their school performance in all disciplines with the exception of Pharmacology I; Pharmacokinetics and Pharmacodynamics. Conclusion: The use of the integrative methodology based on clinical practice resulted in lower dropout and better academic performance. In addition, the use of this methodology promoted greater integration of students in the health care problems and clinical practices.