The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism‐related enzymes is a promising strategy to stimulate immune response. Here, a nanosystem (NLG919/IR780 micelles) with the properties of photothermal conversion and regulation of the tryptophan metabolic pathway is used to suppress the growth of the tumor margin beyond effective PTT and promote tumor PTT and immunotherapy. It is revealed that mild heat treatment promotes the growth of the tumor margin beyond effective PTT for the upregulation of heat shock protein (HSP), indoleamine 2,3‐dioxygenase (IDO), and programmed death‐ligand 1 (PD‐L1). The NLG919/IR780 micelles can effectively inhibit the activity of IDO but do not affect the level of IDO expression. NLG919/IR780 micelles can effectively accumulate in the tumor and can migrate to lymph nodes and the lymphatic system. In vivo antitumor studies reveal that NLG919/IR780 micelles effectively suppress the growth of tumor margin following PTT in primary tumors. NLG919/IR780 micelle‐mediated PTT and IDO inhibition further stimulate the activation of T lymphocytes, inhibiting the growth of distal tumors (abscopal effect). The results demonstrate that the NLG919/IR780 micelles combine PTT and immunotherapy and suppress the tumor margin as well as distal tumor growth post photothermal therapy.

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A new HO-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral HO-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

Nanoparticle-based systems explore not only the delivery efficacy of drugs or contrast agents, but also additional capabilities like reducing the systemic toxicity, especially during cancer chemotherapy. Since some of the noble metal nanoparticles exhibit the catalysis properties which can scavenge the reactive oxygen species (ROS), they can be used as a promising drug delivery platform for reducing the oxidative stress damage in normal tissues caused by some chemotherapy drugs. Herein, in this study, we construct porous Au@Pt nanoparticles and further explore the properties of porous Au@Pt nanoparticles in relieving the oxidative stress damage as well as in tumor growth inhibition by chemo-photothermal co-therapy. The tunable surface pore structure of Au@Pt nanoparticle provides space for Doxorubicin (DOX) loading. cRGD peptide modification enable the DOX-loaded Au@Pt nanoparticles to improve drug delivery properties. The constructed nanocarrier (DOX/Au@Pt-cRGD) shows controlled drug release behavior. Meanwhile, the absorbance peak of the Au@Pt structure in the near-infrared (NIR) portion provides the capacity for in vivo photoacoustic imaging and the high photoconversion efficiency, which make Au@Pt nanoparticle a suitable carrier for photothermal therapy (PTT). Combined with chemotherapy, the nanosystem DOX/Au@Pt-cRGD shows enhanced anticancer therapeutic effects. More importantly, ROS-scavenging activity of Au@Pt alleviates the DOX-induced oxidative stress damage, especially the cardiomyopathy during chemotherapy. Herein, this nanosystem DOX/Au@Pt-cRGD could be explored as reactive oxygen scavenger and drug delivery system for side effects relieving chemo-photothermal combinational therapy.