Background Hyperphosphatemia has been implicated in the development and treatment of various cancers. However, whether it can be used as a direct prognostic marker of colorectal cancer (CRC) has remained unexplored. Given new insights into the importance of hyperphosphatemia in CRC, we sought to evaluate the association of hyperphosphatemia with the clinical outcomes of this disease. Methods In a retrospective analysis of a well-characterized clinic-based cohort with 1,241 CRC patients, we assessed the association of postoperative hyperphosphatemia with patient overall survival. Results Postoperative hyperphosphatemia measured within the first month after surgery was significantly associated with CRC survival. Compared to patients with a normal phosphate level, those with hyperphosphatemia exhibited a significant unfavorable overall survival with a hazard ratio (HR) of 1.84 (95% confidence interval [CI] 1.49–2.29, P=2.6×10−8, (log-rank P=1.2×10−7). Stratified analyses indicated the association was more pronounced in patients with colon (HR=2.00, 95% CI 1.57–2.56, P=3.17×10−8) but not rectal cancer (HR=0.96, 95% CI 0.58–1.59, P=0.889) (P interaction=0.023), as well as in those not receiving chemotherapy (HR=2.15, 95% CI 1.59–2.90, P=6.2×10−7) but not in those receiving chemotherapy (HR=1.30, 95% CI 0.92–1.82, P=0.136) (P interaction=0.012). Flexible parametric survival model demonstrated that the increased risk for death conferred by postoperative hyperphosphatemia persisted over 150 months after surgery. Conclusion Our data indicated that postoperative hyperphosphatemia might be used as a prognostic marker of CRC patients after surgery. Since phosphate level is routinely tested in clinics, it may be incorporated into clinical models to predict CRC survival.

Thermal ablation is a widely utilized treatment option for tumors of the liver and pancreas; procedures may be performed intraoperatively or percutaneously, under image guidance (more recently, endoscopy-guided ablation of pancreatic tumors has also been introduced). Through differing mechanisms, radiofrequency ablation, microwave ablation, and cryoablation aim to precisely eradicate tumor, with adequate margins and minimal injury to normal surrounding tissue. Knowledge of thermal ablative risks and complications is crucial for both therapeutic planning and postprocedural management to optimize outcomes and avoid significant patient injury. In this review, we discuss iatrogenic injuries related to thermal ablation of hepatic and pancreatic malignancies.

he paravertebral block is a useful technique for postoperative pain control in patients undergoing oncoplastic breast surgery. The primary focus of most studies on paravertebral blocks has been on opioid consumption in the postanesthesia care unit, 1 postoperative pain scores, 2,3 and overall quality of recovery. 4 Although the evidence appears strong for perioperative pain and recovery outcomes, studies have not explored differences in pain score at the time of hospital discharge among patients who undergo paravertebral block.A recent observational study 5 evaluating a wide variety of operations found that higher pain score at the time of hospital discharge was associated

No abstract