ROM early 1958, until the registering of new cases ended in May 1965, 6368 case reports entered the Central Registry of the Cooperative Study of Intracranial Aneurysms and Subarachnoid Hemorrhage from ~0 participating university centers (Table 1). These cases had in common either a history of spontaneous non-traumatic subarachnoid hemorrhage (SAH), or the finding of an intracranial aneurysm or arteriovenous malformation (AVM). Each case was reported on a standard set of protocol forms which encompassed some 3080 items of coded information. To these forms were usually appended a narrative summary, reproductions of diagnostic anglograms, copies of operative notes, and pathology reports.

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Abstract://. Objectives and Design of Randomized Aneurvsm Studv• Four selected treatments, namely, regulated bed rest, drug-induced hypotension, caroti( ligation, and intracranial surgery, were randomly allocated with respect to location of thi aneurysm and interval following last bleed. The objective of the Study was to answer the ques tion. "What mode of treatment offers a patient with a single ruptured intracranial aneurysn during the previous three months the highest probability of optimal results with respect to sur vival, residual neurological deficit, capacity for self-care, and gainful employment?" Variou treatments were suspended at specific intervals when a particular mode of therapy became in ferior to the others.A group of 33 patients was disqualified after treatment was randomly allocated. Th numbers of protocols remaining for analysis within each treatment category were 202 fc regulated bed rest, 309 for drug-induced hypotension, 187 for carotid ligation, and 274 for ir tracranial surgery.

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