The work is partly supported by Direction Générale de l'Aviation Civile (project n°2014 930818). ManuscriptA case study of the effects of foam and seat pan inclination on the deformation of seated buttocks measured using MRI Occupational ApplicationsWe investigated the effects of seat pan inclination and foam on the deformation of the seated buttocks using an upright MRI system. From observations among four healthy males, we found that soft tissue deformation under the ischial tuberosity (IT) could be reduced not only by using a soft cushion, but also by decreasing the shear force on the seat pan surface. These results suggest that soft tissue deformation could be used as an objective measure for assessing seating discomfort and injury risk, by accounting for the effects of both contact pressure and shear. We also confirmed that the gluteus maximus (GM) muscle displaced away from the IT once seated. As peak pressure and shear are most likely located below the IT, more realistic computational human body models in this region are needed that consider muscle sliding.